Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system

Metabolic Brain Disease
Juliana LenziAna L B Zeni

Abstract

Oxidative stress has been claimed a place in pathophysiology of depression; however, the details of the neurobiology of this condition remains incompletely understood. Recently, treatments employing antioxidants have been thoroughly researched. Ferulic acid (FA) is a phenolic compound with antioxidant and antidepressant-like effects. Herein, we investigated the involvement of the antioxidant activity of chronic oral FA treatment in its antidepressant-like effect using the tail suspension test (TST) and the forced swimming test (FST) in mice. The modulation of antioxidant system in blood, hippocampus and cerebral cortex was assessed after stress induction through TST and FST. Our results show that FA at the dose of 1 mg/kg has antidepressant-like effect without affecting locomotor activity. The stress induced by despair tests was able to decrease significantly the activities of superoxide dismutase (SOD) in the blood, catalase (CAT) in the blood and cerebral cortex and glutathione peroxidase (GSH-Px) in the cerebral cortex. Thiobarbituric acid-reactive substances (TBA-RS) levels were increased significantly in the cerebral cortex. Furthermore, the results show that FA was capable to increase SOD, CAT and GSH-Px activities and de...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1992·Free Radical Biology & Medicine·E Graf
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1981·Methods in Enzymology·A Wendel
Mar 14, 2000·Redox Report : Communications in Free Radical Research·D E LaaksonenC K Sen
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·F BaiP Skolnick
Nov 1, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lijian YuTingxi Yu
Apr 3, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F Cícero Bezerra FelipeGlauce S de Barros Viana
Jun 19, 2007·Biological Psychiatry·Kenji HashimotoMasaomi Iyo
Oct 1, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mauricio P CunhaAna Lúcia S Rodrigues
Jan 28, 2009·Neurochemistry International·Giancarlo LuccaJoão Quevedo
Feb 11, 2010·Behavioural Brain Research·Kelly R LobatoAna Lúcia S Rodrigues
Sep 3, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andréa D E ZomkowskiAna Lúcia S Rodrigues
Sep 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dharmendra Kumar Maurya, Thomas Paul Asir Devasagayam
May 24, 2011·Pharmacological Reports : PR·Iwona Inkielewicz-Stępniak
Aug 13, 2011·Pharmacology, Biochemistry, and Behavior·Basel A Abdel-Wahab, Ragaa H Salama
Jun 7, 2012·CNS Drugs·Giovanni ScapagniniGiovannangelo Oriani
Jun 16, 2012·International Journal of Medical Sciences·Xiaohong XuTongfeng Zhao
Jul 11, 2012·Neuroscience and Biobehavioral Reviews·Matthew N HillJoanne Weinberg
Oct 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung-Yup LeeChi-Un Pae
Nov 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chirayu D PandyaAnilkumar Pillai
Dec 25, 2012·Neuroscience and Biobehavioral Reviews·Paul WillnerCatherine Belzung
May 22, 2013·Journal of Affective Disorders·Pamela D PilkingtonAnthony F Jorm
Jan 1, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cesare Mancuso, Rosaria Santangelo
Mar 1, 2014·Cell Biochemistry and Function·André F RodriguesDébora Delwing Dal Magro
Apr 9, 2014·The Journal of Pharmacy and Pharmacology·Ana L B ZeniCarla I Tasca
May 27, 2014·Neuroscience and Biobehavioral Reviews·Steven MoylanMichael Maes
Aug 15, 2008·Food Chemistry·Zhaohui Zhao, Mohammed H Moghadasian

❮ Previous
Next ❯

Citations

Jan 8, 2019·Critical Reviews in Food Science and Nutrition·Raffaella Colombo, Adele Papetti
Aug 9, 2019·Molecular Nutrition & Food Research·Kazunori SasakiHiroko Isoda
Apr 9, 2020·Anais Da Academia Brasileira De Ciências·Bruno VeberAna Lúcia B Zeni
May 11, 2017·Nutrients·Dominik SzwajgierKatarzyna Pustelniak
Jul 30, 2019·Journal of Food Biochemistry·Saroj Yadav, Jayadeep Padmanbhan Appukuttan
Nov 30, 2019·Critical Reviews in Food Science and Nutrition·Ixchel Osorio-PazSilvestre Alavez
Dec 6, 2017·Acta Neuropsychiatrica·Patrick R SumanCilene Lino de Oliveira
Jun 14, 2017·Neurochemical Research·Tanveer SinghRajesh Kumar Goel
Mar 14, 2018·Nutrition Reviews·Ewelina KurtysErik F J de Vries
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lúcio Ricardo Leite DinizDamião Pergentino de Sousa
Nov 22, 2019·Frontiers in Neuroscience·Susan Westfall, Giulio Maria Pasinetti
Sep 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yang QiaoMing He
Aug 20, 2017·Metabolic Brain Disease·Ana Paula DalmagroAna Lúcia Bertarello Zeni
Feb 7, 2021·Neurochemical Research·Surabhi ThapliyalRavi Gandham
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yujin ChoiSeung-Hun Cho
Nov 19, 2019·European Journal of Pharmacology·Wenhao XiaJulia Hoeng
Feb 21, 2019·Pharmacology, Biochemistry, and Behavior·Ana Lúcia Bertarello ZeniAna Paula Dalmagro
Jun 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlSimona Bungau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.