Ferulic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NADPH oxidase and NF-κB pathway

International Immunopharmacology
Yan-Jun CaoLang-Chong He

Abstract

Ferulic acid (FA) is a dietary phenolic acid and has a wide range of therapeutic effects, including anti-aging, antitumor activity and antihypertensive effects. The aim of present study was to evaluate the inhibitory effects of FA on cell inflammation and oxidative stress against hydrogen peroxide (H2O2)-induced injury in rat vascular smooth muscle cells (VSMCs) in vitro. VSMCs were pretreated with FA 2h before H2O2 incubation. The results suggested that FA inhibited H2O2-induced cell injury by reducing the MDA and increasing the SOD activity and GSH content. In rat VSMCs exposed to H2O2, FA increased the cell viability and restored the mitochondrial membrane depolarization. The level of ROS generation was reduced by pretreatment with FA through inhibiting the expression of NADPH oxidase and down-regulating MAPK and AKT pathways. We found that H2O2 stimulated the production of IL-6, IL-1β, TNF-α and NO, which could be reduced by pretreatment with FA through inhibiting the p-NF-κB as well as the iNOS expression. In conclusion, our results show that FA may serve as a novel drug in the treatment of these pathologies by inhibiting NADPH oxidase and NF-κB and subsequently decreasing VSMC oxidative stress and inflammation. These sugg...Continue Reading

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Citations

Apr 6, 2016·International Journal of Endocrinology·Ablikim AblizRongze Sun
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ningning ZhangBaodong Zheng
Jan 1, 2020·Environmental Science and Pollution Research International·Ayman M MahmoudSanaa M Abd El-Twab
Jun 4, 2020·BMC Complementary Medicine and Therapies·Xuefeng LiXiangxiang Wei
Jun 24, 2017·Clinical and Experimental Pharmacology & Physiology·Weiyan GongXiaojing Zhang
Sep 4, 2020·Journal of Ethnopharmacology·Abdelhakim BouyahyaNaoual El Menyiy
Sep 17, 2021·Molecular and Cellular Biochemistry·Victor Emanuel Miranda SoaresDébora Tavares de Resende E Silva

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