Ferulic acid inhibits interleukin 17-dependent expression of nodal pathogenic mediators in fibroblast-like synoviocytes of rheumatoid arthritis

Journal of Cellular Biochemistry
Ramamoorthi Ganesan, Mahaboobkhan Rasool

Abstract

Interleukin 17 (IL-17), a proinflammatory cytokine produced by T helper (Th) 17 cells, potentially controls fibroblast-like synoviocytes (FLS)-mediated disease activity of rheumatoid arthritis (RA) via IL-17/ IL-17 receptor type A (IL-17RA)/signal transducer and activator of transcription 3 (STAT-3) signaling cascade. This has suggested that targeting IL-17 signaling could serve as an important strategy to treat FLS-mediated RA progression. Ferulic acid (FA), a key polyphenol, attenuates the development of gouty arthritis and cancer through its anti-inflammatory effects, but its therapeutic efficiency on IL-17 signaling in FLS-mediated RA pathogenesis remains unknown. In the current study, FA markedly inhibited the IL-17-mediated expression of its specific transmembrane receptor IL-17RA in FLS isolated from adjuvant-induced arthritis (AA) rats. Importantly, FA dramatically suppressed the IL-17-mediated expression of toll-like receptor 3 (TLR-3), cysteine-rich angiogenic inducer 61 (Cyr61), IL-23, granulocyte-macrophage colony stimulating factor (GM-CSF) in AA-FLS via the inhibition of IL-17/IL-17RA/STAT-3 signaling cascade. In addition, FA significantly decreased the formation of osteoclast cells and bone resorption potential i...Continue Reading

References

Sep 12, 2002·Arthritis Research·Nobuyuki UdagawaTatsuo Suda
May 4, 2007·Current Opinion in Pharmacology·Dinesh KhannaBharat B Aggarwal
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ji Hyeon JuHo-Youn Kim
Apr 29, 2009·Journal of Computational Chemistry·Garrett M MorrisArthur J Olson
Jul 31, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Myeung Su LeeJaemin Oh
Sep 24, 2009·Current Rheumatology Reports·Sarah L Gaffen
Feb 25, 2011·Annals of the Rheumatic Diseases·Arnaud Hot, Pierre Miossec
Jun 19, 2012·Journal of Autoimmunity·Marie-Christophe BoissierGéraldine Falgarone
Nov 14, 2012·Nature Reviews. Rheumatology·Nunzio Bottini, Gary S Firestein
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra M J PaulissenErik Lubberts
Jul 17, 2013·Therapeutic Advances in Musculoskeletal Disease·Herbert Kellner
Dec 24, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Wenhua ZhuShemin Lu
Jan 21, 2015·Current Opinion in Rheumatology·Jason D Turner, Andrew Filer
Apr 25, 2015·Nature Reviews. Rheumatology·Erik Lubberts
May 20, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kanagalakshmi AmbothiAgilan Balupillai
May 23, 2015·Journal of Autoimmunity·Natasa IsailovicCarlo Selmi
Dec 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Minxi LaoHanshi Xu
Jul 13, 2016·Scientific Reports·Sara Remuzgo-MartínezMiguel A González-Gay
Nov 20, 2016·Rheumatology·Ajay NirulaAlison L Budelsky
Feb 27, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sumit GhoshParames C Sil
Aug 5, 2017·Nature Reviews. Rheumatology·Jessica McHugh

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