Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats.

Acta Pharmacologica Sinica
Chin-yi ChengChing-liang Hsieh

Abstract

Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) provides neuroprotection against apoptosis in a transient middle cerebral artery occlusion (MCAo) model. This study was to further investigate the anti-apoptotic effect of FA during reperfusion after cerebral ischemia. Rats were subjected to 90 min of cerebral ischemia followed by 3 or 24 h of reperfusion after which they were sacrificed. Intravenous FA (100 mg/kg) administered immediately after middle cerebral artery occlusion (MCAo) or 2 h after reperfusion effectively abrogated the elevation of postsynaptic density-95 (PSD-95), neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), nitrotyrosine, and cleaved caspase-3 levels as well as apoptosis in the ischemic cortex at 24 h of reperfusion. FA further inhibited Bax translocation, cytochrome c release, and p38 mitogen-activated protein (MAP) kinase phosphorylation. Moreover, FA enhanced the expression of gamma-aminobutyric acid type B receptor subunit 1 (GABA(B1)) in the ischemic cortex at 3 and 24 h of reperfusion. In addition, nitrotyrosine-positive cells colocalized with cleaved caspase-3-positive cells, and phospho-p38 MAP kinase-positive cells colocalized with nitrotyrosine- and Bax-positive cel...Continue Reading

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Citations

Aug 27, 2011·Chinese Medicine·Yi-Chian Wu, Ching-Liang Hsieh
May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Mijanur RahmanMd Ibrahim Khalil
Jul 10, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ying-Jin ZhangPing Ren
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Feb 7, 2021·Neurochemical Research·Surabhi ThapliyalRavi Gandham
Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei CuiMaolin He
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Aug 20, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Hossein Amini-KhoeiMohammad Rahimi-Madiseh

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