Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3β/NF-κB/CREB pathway.

Life Sciences
Liping CaoShinan Nie

Abstract

Ferulic acid (FA) is a component found in plants that has free radical scavenging and liver-protective properties. Acute liver injury (ALI) is a serious complication of sepsis and is closely associated with changes in the levels of inflammatory factors. This study was taken to examine the role of FA in cecal ligation and perforation (CLP)-induced murine ALI and lipopolysaccharide (LPS)-induced cellular ALI models. An in vivo ALI model was established by performing CLP surgery on C57BL/6 mice. After the ALI model was established, mice were examined for liver injury, including HE staining to observe tissue sections, the percentage of liver/body weight and inflammatory factor levels. Myeloperoxidase (MPO), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were measured in liver or serum using commercial kits. An in vitro ALI model was established using LPS-stimulated RAW264.7 cells. Cell viability was measured by MTT method and the intracellular levels of IL-10, IL-1β, IL-6, IL-12 and TNF-α inflammatory factors were measured using kits. The expression of GSK-3β, NF-κB and CREB was measured by western blot or immunofluorescence. FA pretreatment significantly reduced liver/body weight ratio, decreased MP...Continue Reading

References

Dec 2, 2014·Pharmacology & Therapeutics·Eleonore BeurelRichard S Jope
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
May 31, 2017·Journal of Hepatology·Luiz Eduardo Baggio SavioRobson Coutinho-Silva
Jan 9, 2019·Frontiers in Immunology·Evangelos TriantafyllouLucia A Possamai
Jan 1, 2020·Environmental Science and Pollution Research International·Ayman M MahmoudSanaa M Abd El-Twab

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