Ferulic Acid Protected from Kidney Ischemia Reperfusion Injury in Mice: Possible Mechanism Through Increasing Adenosine Generation via HIF-1α

Inflammation
Qin ZhouBin Wang

Abstract

Ferulic acid (FA), derived from fruits and vegetables, is well-known as a potent antioxidant of scavenging free radicals. However, the role and underlying mechanism of FA on kidney ischemia reperfusion (I/R) injury are limited. Here, we explored the effects of FA on kidney I/R injury. The kidney I/R injury models were carried out by clamping bilateral pedicles for 35 min followed by reperfusion for 24 h. Mice were orally pretreated with different doses of FA for three times 24 h before I/R. The renal function was assessed by serum creatine (Scr) and blood urea nitrogen (BUN). Kidney histology was examined by hematoxylin and eosin (HE) staining and terminal deoxynucleotidly transferased UTP nick-end labeling (TUNEL) assay. Proinflammatory cytokines, caspase-3 activity, adenosine generation, adenosine signaling molecules, and hypoxia inducible factor-1 alpha (HIF-1α) were also detected, respectively. The siHIF-1α adenovirus vectors were in vivo used to inhibit the expression of HIF-1α. The results showed that FA significantly attenuated kidney damage in renal I/R-operated mice as indicated by reducing levels of Scr and BUN, ameliorating renal pathological structural changes, and tubular cells apoptosis. Moreover, FA pretreatment ...Continue Reading

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Citations

Sep 3, 2020·Human & Experimental Toxicology·Ganyang Li, Xiaohong Huang
Jul 10, 2020·Nature Reviews. Nephrology·Karen M DwyerSimon C Robson
Mar 19, 2019·BioMed Research International·Gabriela F Buys-GonçalvesDiogo B de Souza
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Aug 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenru SuSong Guo Zheng
Mar 18, 2020·Food Science & Nutrition·Chuanying RenShuwen Lu
Feb 2, 2021·Frontiers in Immunology·Xiangyun LiXiaoyi Yuan
May 21, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amira AwadallaAhmed A Shokeir
Jul 27, 2021·Frontiers in Molecular Biosciences·Xin HouYanhong Liao

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Methods Mentioned

BETA
flow cytometry
electrophoresis
PCR
ELISA
ubiquitination

Software Mentioned

Image Lab

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