Ferulic Acid Regulates the Nrf2/Heme Oxygenase-1 System and Counteracts Trimethyltin-Induced Neuronal Damage in the Human Neuroblastoma Cell Line SH-SY5Y

Frontiers in Pharmacology
Stefania CatinoCesare Mancuso

Abstract

Over the past years, several lines of evidence have pointed out the efficacy of ferulic acid (FA) in counteracting oxidative stress elicited by β-amyloid or free radical initiators, based on the ability of this natural antioxidant to up-regulate the heme oxygenase-1 (HO-1) and biliverdin reductase (BVR) system. However, scarce results can be found in literature regarding the cytoprotective effects of FA in case of damage caused by neurotoxicants. The aim of this work is to investigate the mechanisms through which FA exerts neuroprotection in SH-SY5Y neuroblastoma cells exposed to the neurotoxin trimethyltin (TMT). FA (1-10 μM for 6 h) dose-dependently increased both basal and TMT (10 μM for 24 h)-induced HO-1 expression in SH-SY5Y cells by fostering the nuclear translocation of the transcriptional activator Nrf2. In particular, the co-treatment of FA (10 μM) with TMT was also responsible for the nuclear translocation of HO-1 in an attempt to further increase cell stress response in SH-SY5Y cells. In addition to HO-1, FA (1-10 μM for 6 h) dose-dependently increased the basal expression of BVR. The antioxidant and neuroprotective features of FA, through the increase of HO activity, were supported by the evidence that FA inhibited...Continue Reading

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Citations

Aug 30, 2016·Frontiers in Nutrition·Mario CaruanaNeville Vassallo
Mar 21, 2017·Neuropharmacology·Cesare Mancuso
Dec 27, 2018·International Journal of Molecular Sciences·Huiju Lee, Yoon Kyung Choi
Jul 20, 2019·Phytotherapy Research : PTR·Alireza TavakkoliGholamreza Karimi
Aug 4, 2018·International Journal of Molecular Sciences·Mariapaola NittiAnna Lisa Furfaro
Oct 9, 2019·Journal of Zhejiang University. Science. B·Zhi-Hao TaoYuan-Jiang Pan
May 28, 2020·International Journal of Molecular Sciences·Mark F McCarty, Aaron Lerner
Sep 5, 2019·Chemistry & Biodiversity·Yanping ZhouGuiqing Jia
Jul 24, 2020·Scientific Reports·Michał JuszczakKatarzyna Woźniak
Aug 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eun-Jeong KohBoo-Yong Lee
Apr 5, 2020·International Journal of Molecular Sciences·Ines AmaraVittorio Calabrese
Jan 14, 2017·Molecular Neurobiology·Emanuela MhillajCesare Mancuso
Feb 10, 2021·Expert Opinion on Therapeutic Targets·Ranjana BhandariAnurag Kuhad
Apr 13, 2019·Mechanisms of Ageing and Development·Yini LiangYingcai Niu
Apr 17, 2021·Pharmacological Reports : PR·Lovedeep SinghRajbir Bhatti
Jul 6, 2021·Free Radical Biology & Medicine·Cesare Mancuso

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Methods Mentioned

BETA
FCS
protein assay
electrophoresis
nuclear translocation

Software Mentioned

Leica Confocal
LCSLite
Leica Confocal Software ( LCS Lite
Prism
GraphPad

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