Ferumoxytol-Enhanced Magnetic Resonance Imaging in Late-Stage CKD

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Srinivasan MukundanAndrew M Siedlecki

Abstract

Ferumoxytol is a superparamagnetic iron oxide particle encapsulated by a semisynthetic carbohydrate with properties that can be used by the nephrologist for diagnosis and therapy. Ferumoxytol is approved by the US Food and Drug Administration for treating iron deficiency anemia in the setting of chronic kidney disease, but not for clinical diagnostic imaging. It has gained appeal as a magnetic resonance imaging contrast agent in patients with estimated glomerular filtration rates < 30mL/min/1.73m(2) in whom gadolinium-based contrast magnetic resonance imaging agents are relatively contraindicated because of the association with gadolinium deposition and nephrogenic systemic fibrosis. Ferumoxytol metabolism is not dependent on kidney function, but rather is removed from the circulation by the reticuloendothelial system of the liver, spleen, and bone marrow. Additionally, the prolonged intravascular half-life (>14 hours) of ferumoxytol allows for longer image acquisition and repeat imaging, if necessary. In patients with contraindications for gadolinium contrast agents, ferumoxytol is an alternative agent for vascular assessment, including patency and course.

Associated Clinical Trials

References

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Citations

Jun 14, 2016·Kidney International·Ryan M WilliamsDaniel A Heller
Sep 2, 2016·Angiogenesis·Saskia von StillfriedPeter Boor
Oct 5, 2018·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Akihiro NishieHiroshi Honda
Mar 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Shiman WuZhenwei Yao
Sep 15, 2020·Clinical Practice and Cases in Emergency Medicine·Ayaz AghayevAndrew M Siedlecki
May 8, 2018·Clinical Radiology·E D LehrmanD Saloner

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