FES kinase participates in KIT-ligand induced chemotaxis

Biochemical and Biophysical Research Communications
Edwige VoissetPaulo De Sepulveda

Abstract

FES is a cytoplasmic tyrosine kinase activated by several membrane receptors, originally identified as a viral oncogene product. We have recently identified FES as a crucial effector of oncogenic KIT mutant receptor. However, FES implication in wild-type KIT receptor function was not addressed. We report here that FES interacts with KIT and is phosphorylated following activation by its ligand SCF. Unlike in the context of oncogenic KIT mutant, FES is not involved in wild-type KIT proliferation signal, or in cell adhesion. Instead, FES is required for SCF-induced chemotaxis. In conclusion, FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.

References

May 8, 2002·Nature Reviews. Molecular Cell Biology·Peter Greer
Aug 23, 2002·Molecular and Cellular Biology·Andrew W B Craig, Peter A Greer
Jan 7, 2004·The Journal of Biological Chemistry·Julie BaylePaulo De Sepulveda
Oct 16, 2004·Molecular and Cellular Biology·Charles E LaurentThomas E Smithgall
Dec 31, 2004·Stem Cells·Johan LennartssonR Shivakrupa

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Citations

Jun 13, 2014·Open Biology·Mirko PesceAntonia Patruno

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