Apr 28, 2016

FET proteins regulate lifespan and neuronal integrity

Scientific Reports
Martine TherrienJ Alex Parker

Abstract

The FET protein family includes FUS, EWS and TAF15 proteins, all of which have been linked to amyotrophic lateral sclerosis, a fatal neurodegenerative disease affecting motor neurons. Here, we show that a reduction of FET proteins in the nematode Caenorhabditis elegans causes synaptic dysfunction accompanied by impaired motor phenotypes. FET proteins are also involved in the regulation of lifespan and stress resistance, acting partially through the insulin/IGF-signalling pathway. We propose that FET proteins are involved in the maintenance of lifespan, cellular stress resistance and neuronal integrity.

Mentioned in this Paper

DRD3
Protein Family
Caenorhabditis elegans
Regulation of Biological Process
Neurons
Somatomedins
Nerve Degeneration
TAF15 protein, human
TAF15 gene
Motor Neurons

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