Fetal adrenal gland alterations in a rat model of adverse intrauterine environment

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Karine BibeauMichèle Brochu

Abstract

By feeding a low-sodium diet to dams over the last third of gestation, we have developed an animal model of intrauterine growth restriction (IUGR). Given that fetal adrenal development and maturation occur during late gestation in rats, the aim of this study was to evaluate the expression of proteins and enzymes involved in steroidogenesis and catecholamine synthesis in adrenal glands from IUGR fetuses. A gene microarray was performed to investigate for alteration in the pathways participating in hormone production. Results show that increased aldosterone serum concentrations in IUGR fetuses were associated with higher mRNA adrenal levels of angiotensin II receptor type 1 (AT(1)R) and cytochrome P450 aldosterone synthase in response to decreased serum sodium content. Conversely, reduced serum corticosterone concentrations in these fetuses appear to result from alterations in gene expression involved in cholesterol metabolism, such as the augmented apolipoprotein E levels, and in steroidogenesis, like the decreased levels of cytochrome P45011beta-hydroxylase. Furthermore, increased AT(2)R expression and the presence of hypoxia and oxidative stress may, in turn, explain the higher adrenal mRNA levels of enzymes involved in catech...Continue Reading

References

Dec 1, 1991·Asia-Oceania Journal of Obstetrics and Gynaecology·T HiraokaY Kishimoto
Dec 1, 1989·The Journal of Endocrinology·A ChatelainJ P Dupouy
Dec 1, 1989·Developmental Biology·K Seidl, K Unsicker
Jan 1, 1985·The Journal of Physiology·F J Seidler, T A Slotkin
May 1, 1995·The American Journal of Physiology·S ShanmugamJ M Gasc
Dec 1, 1994·The American Journal of Physiology·S ShanmugamJ M Gasc
Jul 3, 1998·American Journal of Respiratory Cell and Molecular Biology·C D HartR A Simmons
Feb 10, 1999·The American Journal of Physiology·P E McEwanC J Kenyon
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Mar 17, 1999·American Journal of Obstetrics and Gynecology·E Roy-ClavelM Brochu
Jun 29, 1999·Endocrinology·F MitaniY Ishimura
Sep 12, 2000·Current Hypertension Reports·G Wolf
Jan 26, 2002·Pediatric Research·Julie MametYvette Dalmaz
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Marie-Claude BattistaMichèle Brochu
Jul 9, 2004·The Journal of Veterinary Medical Science·Masako YamamotoKazuyoshi Arishima
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Nov 13, 2004·The Journal of Physiology·Sophie BédardMichèle Brochu
Mar 19, 2005·The Journal of Physiology·Marie-Claude BattistaMichèle Brochu
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Feb 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jean St-LouisMichèle Brochu
Dec 14, 2006·Pflügers Archiv : European journal of physiology·R BournaudT Shimahara
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg

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Citations

May 14, 2011·Reproductive Sciences·Naseem M KhorramOmid Khorram
Sep 7, 2016·Maternal Health, Neonatology and Perinatology·Habiba KapayaPamela V Loughna
Jul 25, 2017·Clinical and Experimental Hypertension : CHE·Pavel SvitokMichal Zeman
Dec 19, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zohre Farzad MohajeriSoghra Khazardoost
Feb 6, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jose Garcia-FloresRicardo Sainz de la Cuesta

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