PMID: 9440776Jan 24, 1998Paper

Fetal airway wound repair: a new frontier

Archives of Otolaryngology--head & Neck Surgery
J E DoharPatricia A Hebda

Abstract

Fetal dermal repair is regenerative and scarless until middle to late gestation, when there is a transition to fibrotic repair. Fetal skeletal muscle and tendon undergo repair with fibrosis similar to the process in adults. This study addresses whether fetal mucosal healing is regenerative and scarless. Anesthetized pregnant rabbits underwent laparotomy and controlled hysterotomy at 21 to 23 days' gestation (term is 31 days). A midline thyrotomy was made, followed by cricoidotomy and circumferential cauterization of the subglottic mucosa. A similar insult was applied to weanlings. The data were collected in 2 groups. One group was followed to term and killed at 4 weeks. A second group was killed after 6 days (30 days' gestation). The weanlings were killed at similar points. The larynges were harvested and processed for histological and morphometric analysis. Three litters were followed to term. Of these, 1 was not recovered; in the other two, 7 of 8 manipulated fetuses were found and 3 of 8 were viable. The fourth litter was harvested after 6 days; all 4 injured fetuses were recovered and viable. All animals in the fetal injury groups healed with complete regeneration of the airway mucosa. In contrast, weanlings injured post pa...Continue Reading

Citations

Jul 23, 2008·Archives of Otolaryngology--head & Neck Surgery·Todd D OttesonJoseph E Dohar
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Sandeep KathjuLatha Satish
Aug 15, 2006·Journal of Voice : Official Journal of the Voice Foundation·Ryan C BranskiSudha Agarwal
Dec 1, 2001·British Journal of Plastic Surgery·R D PriceH A Navsaria
Feb 24, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·A J RadfarP A Hebda
Oct 19, 2017·Current Pathobiology Reports·Aron Parekh, Patricia A Hebda
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aiping LuJohnny Huard
Sep 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P A Hebda, J E Dohar
Dec 29, 1998·International Journal of Pediatric Otorhinolaryngology·N A GoldsteinJ E Dohar
Apr 6, 1999·International Journal of Pediatric Otorhinolaryngology·J E DoharP A Hebda

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