Fetal alcohol syndrome at the cellular level

Addiction Biology
John W Olney

Abstract

A single exposure of infant rats or mice to ethanol during synaptogenesis (mid to late pregnancy for humans) can cause developing neurons to commit suicide (die by apoptosis) on a massive scale. The neuronal loss demonstrated in recent studies is more severe and much more widely distributed (many brain regions, plus spinal cord and retina) than has been documented in prior animal ethanol studies. By suppressing neuronal activity via NMDA glutamate and GABAA receptors, ethanol disrupts synaptogenesis, thereby activating in developing neurons a programmed signal to commit suicide. These recent findings help clarify important aspects of the fetal alcohol syndrome, and demonstrate the usefulness of an in vivo infant rodent model for studying the neurotoxic effects of ethanol on the developing central nervous system.

References

Mar 1, 1979·Early Human Development·J Dobbing, J Sands
Apr 1, 1979·Journal of the Neurological Sciences·J PeifferB Volk
Jan 1, 1978·The Journal of Pediatrics·S K ClarrenD W Smith
Aug 1, 1975·Teratology·K L Jones, D W Smith
Feb 1, 1990·Alcoholism, Clinical and Experimental Research·D J Bonthius, J R West
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·J R WestB L Marcussen
Mar 31, 1989·Science·D M LovingerF F Weight
Sep 1, 1987·Journal of Studies on Alcohol·G J ConnorsD L Thompson
Nov 3, 1973·Lancet·K L Jones, D W Smith
Nov 1, 1983·Neuropediatrics·K WisniewskiQ Qazi
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·R A HarrisT V Dunwiddie
Apr 2, 1993·Science·H Komuro, P Rakic
Jun 1, 1996·Pediatric Research·C IkonomidouJ W Olney
Sep 1, 1996·Alcoholism, Clinical and Experimental Research·S N MattsonK L Jones
Nov 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S Borg
Feb 11, 1997·Pediatrics·V W SwayzeN C Andreasen
Apr 18, 1998·The American Journal of Psychiatry·C FamyA S Unis
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D PohlC Ikonomidou
Mar 27, 2001·Developmental Medicine and Child Neurology·S L ArchibaldT L Jernigan
Apr 6, 2001·Seminars in Clinical Neuropsychiatry·A P Streissguth, K O'Malley
Apr 17, 2001·The Behavioral and Brain Sciences·J P Aggleton, M W Brown
Jun 21, 2001·Molecular Neurobiology·S Mennerick, C F Zorumski
Jul 13, 2001·Neurobiology of Disease·K DikranianJ W Olney
Mar 8, 2002·Brain Research. Developmental Brain Research·John W OlneyChrysanthy Ikonomidou
Mar 16, 2002·Neurobiology of Disease·John W OlneyKevin A Roth
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Petra BittigauChrysanthy Ikonomidou
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Tatyana TenkovaJohn W Olney
Sep 23, 2003·Cell Death and Differentiation·C YoungJ W Olney
Mar 23, 2004·Current Molecular Medicine·Chainllie YoungJohn W Olney

❮ Previous
Next ❯

Citations

Mar 9, 2012·Journal of Proteome Research·Daniel B McClatchyJohn R Yates
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia VaglenovaClark Randal
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Suzhen Chen, Michael E Charness
Jan 17, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Consuelo GuerriEdward P Riley
Feb 22, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A D ThomsonE J Marshall
Feb 3, 2006·Environmental Health Perspectives·Henrik AlmMichael Stigson
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giorgi KharebavaMichal Hetman
Jan 12, 2016·Biomolecules·Antje Anji, Meena Kumari
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Arindam P GhoshKevin A Roth
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Mathias ZinkRainer Spanagel
Aug 16, 2005·Pharmacology & Therapeutics·Nora D Volkow, Ting-Kai Li
Feb 3, 2009·Alcoholism, Clinical and Experimental Research·Lisa M ChiodoJohn H Hannigan
Jan 31, 2018·Frontiers in Neuroanatomy·Stevie C BiffenErnesta M Meintjes
Jun 30, 2004·Addiction Biology·Larry Burd
Apr 13, 2007·Language, Speech, and Hearing Services in Schools·Yvette D Hyter
Feb 25, 2005·Neuroreport·Mathias Zink, Rainer Spanagel
May 7, 2008·Current Opinion in Anaesthesiology·Fernande Lois, Marc De Kock
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ricardo Noboro IsayamaEdna Nanami Yamasaki
Nov 26, 2009·Alcoholism, Clinical and Experimental Research·Catherine LebelChristian Beaulieu
Jan 28, 2010·Alcoholism, Clinical and Experimental Research·Michael P Puglia, C Fernando Valenzuela
Jul 22, 2010·Alcoholism, Clinical and Experimental Research·Lisa M ChiodoVirginia Delaney-Black
Jul 22, 2005·Journal of Neuroscience Research·Stephen C Bondy, Arezoo Campbell
Sep 30, 2005·Addiction Biology·M Luisa Murillo-FuentesOlimpia Carreras
Dec 14, 2007·Developmental Neuroscience·Yulan JiangHitoshi Komuro
Sep 12, 2013·Molecular Neurobiology·Juu-Chin LuChih-Tien Wang
May 19, 2012·Alcoholism, Clinical and Experimental Research·Kristen L EckstrandMalcolm J Avison
Sep 13, 2013·Brain Sciences·Benjamin SadrianMariko Saito
Jul 10, 2019·Alcoholism, Clinical and Experimental Research·Ryan N SerioLorraine J Gudas
Apr 17, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Verónica BalaszczukCarlos A Beltramino
Jul 15, 2016·The Nurse Practitioner·Deborah S WalkerCarolyn Herrington
Mar 18, 2011·Alcoholism, Clinical and Experimental Research·Yuanyuan ChenFeng C Zhou
Jun 15, 2011·Journal of Neuroscience Research·Zunji KeJia Luo
Aug 2, 2008·Alcoholism, Clinical and Experimental Research·Catherine LebelChristian Beaulieu
May 24, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jasmine M BrownAndrew J Greenshaw
Nov 23, 2013·Neuropharmacology·Ute BurkhardtJochen Klein
Aug 28, 2021·International Journal of Environmental Research and Public Health·Hiroshi MitomaAasef G Shaikh
Sep 16, 2021·Alcoholism, Clinical and Experimental Research·Valentina LicheriJonathan L Brigman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Brain Research. Developmental Brain Research
John W OlneyChrysanthy Ikonomidou
Mental Retardation and Developmental Disabilities Research Reviews
John W OlneyChrysanthy Ikonomidou
Apoptosis : an International Journal on Programmed Cell Death
John W OlneyChrysanthy Ikonomidou
© 2022 Meta ULC. All rights reserved