Fetal and maternal endocrine changes approaching parturition in the goat: lack of evidence for prostaglandins E2 and F2alpha as signals for luteolysis

Biology of Reproduction
M M FordG D Thorburn

Abstract

We investigated the temporal relationship of fetal cortisol secretion to circulating concentrations of fetal ACTH1-39 and its high-molecular weight precursors in goats. We also measured the concentrations of progesterone, estradiol-17beta estrone sulfate, prostaglandin (PG) E, PGF2alpha, and PGF2alpha metabolite (PGFM) in maternal arterial plasma over the last month of gestation. Prostaglandin concentrations were also measured in utero-ovarian venous plasma. There was a positive association between ACTH1-39 in fetal plasma and the prepartum surge in fetal cortisol that commenced 8 days before labor. The fetal cortisol surge was followed by a simultaneous decrease in maternal progesterone and an increase in plasma estrogens commencing 3-4 days before labor. No change in basal prostaglandin concentration occurred before this time. There was a positive veno-arterial difference of PGE and PGF2alpha across the uterine vascular bed, confirming the uteroplacental unit as a major source of these eicosanoids in the plasma of the pregnant doe. We conclude that the fetal signal for parturition precedes luteolysis by some 5 days and find no evidence of changes in the basal concentrations of PGE and PGF2alpha in maternal plasma at the time ...Continue Reading

Citations

Jul 24, 2004·Animal Reproduction Science·G Jenkin, I R Young
Nov 10, 2007·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Roger SmithHelena C Parkington
Jan 23, 2013·Endocrinology·Roger SmithGemma Madsen
Mar 15, 2011·Reproduction in Domestic Animals = Zuchthygiene·M ProboM C Veronesi
Apr 30, 1999·Physiological Reviews·J A McCrackenJ C Lamsa

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