Fetal assessment in buprenorphine-maintained women using fetal magnetoencephalography: a pilot study

Addiction
Diana Escalona-VargasHari Eswaran

Abstract

In-utero exposure to opioids including buprenorphine (BUP) has been shown to affect fetal activity, specifically heart-rate variability (FHRV) and fetal movement (FM). Our objective was to extract simultaneous recordings of fetal cardiac and brain-related activity in BUP-maintained and non-opioid exposed pregnant women using a novel non-invasive biomagnetic technique. A pilot study was conducted, recording and analyzing biomagnetic data from fetuses of BUP-maintained and non-opioid exposed pregnant women. Signals were acquired with the non-invasive 151-channel SARA (SQUID-Array for Reproductive Assessment) system. Advanced signal-processing techniques were applied to extract fetal heart and brain activity. University of Arkansas for Medical Sciences (UAMS, Little Rock, Arkansas, USA). Eight BUP-maintained pregnant women from UAMS Women's Mental Health Program between gestational ages (GA) of 29-37 weeks who were treated with 8-24 mg of BUP daily. Sixteen pregnant women with no known opioid exposure in the same GA range were also included. Outcome measures from the fetal heart and brain signals included: heart rate (FHR), FM, FHR accelerations, FHR-FM coupling, FHRV, fetal behavioral states (FBS) and power spectral density (PSD)...Continue Reading

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Citations

Jul 13, 2019·The Journal of Obstetrics and Gynaecology Research·Elijah H BolinHari Eswaran
Nov 10, 2020·Neurophysiologie clinique = Clinical neurophysiology·Fabrice WalloisSahar Moghimi

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