Fetal blood-gas values during fetoscopic myelomeningocele repair performed under carbon dioxide insufflation

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
A A BaschatJ L Miller

Abstract

Fetoscopic myelomeningocele (MMC) repair is performed using intrauterine carbon dioxide (CO2 ) insufflation. Sheep experiments have shown that CO2 insufflation is associated with significant fetal acidemia; however, corresponding data for human pregnancy are not available. We performed umbilical venous cord blood sampling in three patients during fetoscopic MMC repair at 25 + 1, 25 + 3 and 24 + 0 weeks' gestation, respectively. Fetal venous pH at the beginning of CO2 insufflation was 7.36, 7.46 and 7.37, respectively in the three fetuses, and repeat values were 7.28, 7.35 and 7.36 after 181, 159 and 149 min, respectively. The partial pressure of oxygen and CO2 was maintained in the normal range during these times, and pH decrease was less in Patient 3 who received humidified CO2 insufflation. Our observations suggest that, in contrast to sheep experiments, CO2 insufflation during fetoscopic myelomeningocele repair does not cause acidemia in human fetuses. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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Citations

Sep 22, 2018·Prenatal Diagnosis·Sasha SkinnerRyan Hodges
Oct 5, 2018·Prenatal Diagnosis·Sasha SkinnerPhilip DeKoninck
Jul 15, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Luc JoyeuxJan Deprest
Nov 15, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E KassirJ Espinoza
Mar 6, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Sanz Cortes
Nov 22, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B J AmbergP L J DeKoninck
Jan 24, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Sanz CortesM A Belfort
Nov 30, 2018·Minerva ginecologica·Jena L MillerAhmet A Baschat
Jun 7, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Sanz CortesK H Nicolaides
Jul 6, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L JoyeuxJ Deprest
Jun 21, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Sanz CortesM A Belfort
Jul 3, 2020·BMJ : British Medical Journal·Rodrigo Ruano
Jul 20, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K J Moise, J P Spike
Nov 26, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B J AmbergR J Hodges
Jun 1, 2021·American Journal of Obstetrics & Gynecology MFM·Rauvynne N SangaraRamen H Chmait
Aug 17, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R Cruz-MartínezE Hernández-Andrade

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