Because of various prenatal diagnoses, 606 fetal blood samplings were carried out in 562 pregnancies from the gestational week 17 to 38 with use of a 20-gauge needle guided by ultrasound. The procedure was performed on outpatients under local anesthesia and without medication before or after the procedure. Pure fetal blood was obtained at the first attempt in 588 cases. A second attempt was necessary in 18 cases. Maternal blood contamination was never present. Amniotic fluid dilution was noted in 15 cases. At the beginning of our experience only three cords could not be punctured. The duration of the procedure was less than 10 minutes in 90% of cases. Fifty-eight pregnancies were terminated after consideration of the results of the diagnosis, and 504 pregnancies were continued. The complications found in these pregnancies were premature delivery (5%), growth retardation (8%), in utero death (1.1%), and spontaneous abortion (0.8%). In the future this new procedure could replace fetoscopy and initiate an important field of new investigations.
Low molecular weight heparin (PK 10169) does not cross the placenta during the second trimester of pregnancy study by direct fetal blood sampling under ultrasound
Fetal blood sampling from the intrahepatic vein for rapid karyotyping in the second and third trimesters
Rapid chromosome analysis and prenatal diagnosis using fluid from the cystic hygroma, hydrothorax and isolated ascites: new source for chromosome analysis
Transabdominal chorionic villus biopsy in second and third trimesters of pregnancy to determine fetal karyotype
Assessment of changes in blood flow through the lungs and foramen ovale in the normal human fetus with gestational age: a prospective Doppler echocardiographic study
Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
Indications of 1342 fetal cord blood sampling procedures performed as an integral part of high risk pregnancy care
Nationwide study of idiopathic thrombocytopenic purpura in pregnant women and the clinical influence on neonates
Levels and plasma distribution of free and C4b-BP-bound protein S in human fetuses and full-term newborns
Successful treatment of refractory supraventricular tachycardia by repeat intravascular injection of amiodarone in a fetus with hydrops
Placental passage of azathiothymidine (AZT) during the second trimester of pregnancy: study by direct fetal blood sampling under ultrasound
Polymerase chain reaction in the diagnosis of congenital toxoplasmosis: more than two decades of development and evaluation
Changes in alpha 1-acid glycoprotein serum concentrations and glycoforms in the developing human fetus
Cord sampling for the evaluation of oxygenation and acid-base balance in growth-retarded human fetuses
Umbilical amino acid concentrations in appropriate and small for gestational age infants: a biochemical difference present in utero
Effect of diagnostic and therapeutic cordocentesis on maternal serum alpha-fetoprotein concentration
The use of saline solution as a contrast medium in suspected diaphragmatic hernia and renal agenesis
Maternal-fetal glucose gradient in normal pregnancies and in pregnancies complicated by alloimmunization and fetal growth retardation
Deviation in amniotic fluid optical density at a wavelength of 450 nm in Rh-immunized pregnancies from 14 to 40 weeks' gestation: a proposal for clinical management
Benefits of placental biopsies for rapid karyotyping in the second and third trimesters (late chorionic villus sampling) in high-risk pregnancies
Percutaneous umbilical blood sampling: results from a multicenter collaborative registry. The Western Collaborative Perinatal Group
Rapid genome-wide aneuploidy diagnosis using uncultured amniocytes and array comparative genomic hybridization in pregnancy with abnormal ultrasound findings detected in late second and third trimesters
Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter
Complexity of alpha thalassemia: growing health problem with new approaches to screening, diagnosis, and therapy
Retrospective comparison of maternal vs. HPA-matched donor platelets for treatment of fetal alloimmune thrombocytopenia
The relationship of maternal and fetal glucose concentrations in the human from midgestation until term
Biochemistry testing associated with pregnancy and the newborn period -- a lot has changed since you were a baby!
Severe fetal and neonatal hyperthyroidism years after surgical treatment of maternal Graves' disease
Perinatal management of women with immune thrombocytopenic purpura: survey of United States perinatologists
A less invasive treatment strategy to prevent intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia
Doppler ultrasound velocimetry for timing the second intrauterine transfusion in fetuses with anemia from red cell alloimmunization
Initial fetal platelet counts predict the response to intravenous gammaglobulin therapy in fetuses that are affected by PLA1 incompatibility
Defining the role of fluorescence in situ hybridization on uncultured amniocytes for prenatal diagnosis of aneuploidies
Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies
The value of middle cerebral artery peak systolic velocity in the diagnosis of fetal anemia after intrauterine death of one monochorionic twin
A retrospective review of isoimmunized pregnancies managed by middle cerebral artery peak systolic velocity
Early ultrasonographic detection of fetal growth retardation in an ovine model of placental insufficiency
Changes in concentrations of cortisol, dehydroepiandrosterone sulphate and progesterone in fetal and maternal serum during pregnancy
Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn - review on current management and outcome
Release of vasoactive agents during cordocentesis: differences between normally grown and growth-restricted fetuses
Cystic lesions of the fetal kidney: diagnosis and prediction of postnatal function by fetal urine biochemistry
Prenatal diagnosis of trisomy 21 with fetal cells in maternal blood using comparative genomic hybridization
Prenatal diagnosis of fetal cerebral abnormalities by ultrasonography and magnetic resonance imaging
Detection of fetomaternal haemorrhage associated with cordocentesis using serum alpha-fetoprotein and the Kleihauer technique
The role of percutaneous umbilical blood sampling in the management of immune thrombocytopenic purpura
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum
Use of interphase fluorescence in situ hybridization in third trimester fetuses with anomalies and growth retardation
Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses
The fetal intrahepatic umbilical vein as an alternative to cord needling for prenatal diagnosis and therapy
Ultrasonographic method for detection of haemoglobin Bart's hydrops fetalis in the second trimester of pregnancy
Cardiac and extra-cardiac anomalies as indicators for trisomies 13 and 18: a prenatal ultrasound study
A classification of pregnancy losses after invasive prenatal diagnostic procedures: an approach to allow comparison of units with a different case mix
Rapid karyotyping in prenatal diagnosis: a comparative study of the 'pipette method' and the 'in situ' technique for chromosome harvesting
Six years' experience with rapid karyotyping in prenatal diagnosis: correlations between phenotype detected by ultrasound and fetal karyotype
The use of early simultaneous percutaneous umbilical blood sampling (PUBS) and amniocentesis for prenatal fragile X chromosome diagnosis
Maternal serum alpha-fetoprotein, fetal middle cerebral artery blood flow velocity and fetal haemoglobin in pregnancies at risk of fetal anaemia
Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum
Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy
Magnetic resonance imaging and the detection of fetal brain anomalies, injury, and physiologic adaptations
Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction
Is there an association between fetal viral infection and fetal malformation? I. Detection of specific IgM antibodies in the serum of malformed fetuses
Use of cordocentesis in the management of preterm or growth-restricted fetuses with abnormal monitoring
Will it ever be possible to balance the risk of intracranial haemorrhage in fetal or neonatal alloimmune thrombocytopenia against the risk of treatment strategies to prevent it?
Experiences with fetomaternal alloimmune thrombocytopenia at a Swedish hospital over a 10-year period
The role of preimplantation genetic diagnosis in the management of severe rhesus alloimmunization: first unaffected pregnancy: case report
Low fetal morbidity in pregnancy associated with acute and chronic idiopathic thrombocytopenic purpura
Determination of digoxin in the blood of pregnant women, fetuses and neonates before and during anti-arrhythmic therapy, using four immunochemical methods
Evaluation of chromosomal abnormalities and copy number variations in late trimester pregnancy using cordocentesis
Circulating levels of growth hormone, insulin-like growth factor-I and prolactin in normal, growth retarded and anencephalic human fetuses
Estimation of the risk of thrombocytopenia in the offspring of pregnant women with presumed immune thrombocytopenic purpura
Middle cerebral artery peak systolic velocity: is it the standard of care for the diagnosis of fetal anemia?
Reliability of fetal middle cerebral artery velocity measurements: a randomized controlled trial of sonographer training
Peak systolic velocity of fetal middle cerebral artery to predict anemia in Red Cell Alloimmunization in un-transfused and transfused fetuses.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
The Tendon Seed Network
Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.
Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.
Chromatin Regulation and Circadian Clocks
The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.
“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.
Spatio-Temporal Regulation of DNA Repair
DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.