Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: a study of 606 consecutive cases
Abstract
Because of various prenatal diagnoses, 606 fetal blood samplings were carried out in 562 pregnancies from the gestational week 17 to 38 with use of a 20-gauge needle guided by ultrasound. The procedure was performed on outpatients under local anesthesia and without medication before or after the procedure. Pure fetal blood was obtained at the first attempt in 588 cases. A second attempt was necessary in 18 cases. Maternal blood contamination was never present. Amniotic fluid dilution was noted in 15 cases. At the beginning of our experience only three cords could not be punctured. The duration of the procedure was less than 10 minutes in 90% of cases. Fifty-eight pregnancies were terminated after consideration of the results of the diagnosis, and 504 pregnancies were continued. The complications found in these pregnancies were premature delivery (5%), growth retardation (8%), in utero death (1.1%), and spontaneous abortion (0.8%). In the future this new procedure could replace fetoscopy and initiate an important field of new investigations.
References
Citations
Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
Effect of diagnostic and therapeutic cordocentesis on maternal serum alpha-fetoprotein concentration
The use of saline solution as a contrast medium in suspected diaphragmatic hernia and renal agenesis
Severe fetal and neonatal hyperthyroidism years after surgical treatment of maternal Graves' disease
Prenatal diagnosis of fetal cerebral abnormalities by ultrasonography and magnetic resonance imaging
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