Fetal brain growth portrayed by a spatiotemporal diffusion tensor MRI atlas computed from in utero images

NeuroImage
Shadab KhanAli Gholipour

Abstract

Altered structural fetal brain development has been linked to neuro-developmental disorders. These structural alterations can be potentially detected in utero using diffusion tensor imaging (DTI). However, acquisition and reconstruction of in utero fetal brain DTI remains challenging. Until now, motion-robust DTI methods have been employed for reconstruction of in utero fetal DTIs. However, due to the unconstrained fetal motion and permissible in utero acquisition times, these methods yielded limited success and have typically resulted in noisy DTIs. Consequently, atlases and methods that could enable groupwise studies, multi-modality imaging, and computer-aided diagnosis from in utero DTIs have not yet been developed. This paper presents the first DTI atlas of the fetal brain computed from in utero diffusion-weighted images. For this purpose an algorithm for computing an unbiased spatiotemporal DTI atlas, which integrates kernel-regression in age with a diffeomorphic tensor-to-tensor registration of motion-corrected and reconstructed individual fetal brain DTIs, was developed. Our new algorithm was applied to a set of 67 fetal DTI scans acquired from healthy fetuses each scanned at a gestational age between 21 and 39 weeks. Th...Continue Reading

Citations

Oct 9, 2019·Topics in Magnetic Resonance Imaging : TMRI·Daan ChristiaensJana Hutter
Oct 9, 2019·Topics in Magnetic Resonance Imaging : TMRI·András Jakab
Oct 28, 2019·Nature Biomedical Engineering·Ali Gholipour, Simon K Warfield
May 7, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Onur AfacanSimon K Warfield
Aug 21, 2020·Acta Neuropathologica Communications·Ana A BaburamaniMary A Rutherford
Apr 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaojie WangChristopher D Kroenke
Dec 1, 2020·Pediatric Radiology·Fedel Machado-RivasMichael S Gee
Jan 26, 2021·Frontiers in Psychiatry·Femke LammertinkManon J N L Benders
Jan 13, 2021·AJNR. American Journal of Neuroradiology·F Machado-RivasC Jaimes
Apr 20, 2020·Biological Psychiatry·Moriah E Thomason
Mar 25, 2019·NeuroImage·Lana VasungEmi Takahashi
May 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Siân WilsonJonathan O'Muircheartaigh
May 30, 2021·Brain Structure & Function·Haotian LiDan Wu
Jun 18, 2021·European Radiology Experimental·Andras JakabMartin Meuli
Aug 30, 2021·NeuroImage·Davood KarimiAli Gholipour
Sep 7, 2021·Human Brain Mapping·Fedel Machado-RivasCamilo Jaimes
Dec 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Josepheen De Asis-CruzCatherine Limperopoulos

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