Fetal Brain Injury Associated with Parvovirus B19 Congenital Infection Requiring Intrauterine Transfusion

Fetal Diagnosis and Therapy
Emeline MaisonneuveJean-Marie Jouannic

Abstract

Infection with parvovirus B19 (B19V) during pregnancy may cause severe fetal anemia, hydrops, and fe tal death. Furthermore, neurodevelopmental impairment among survivors may occur despite appropriate prenatal management, including intrauterine transfusion (IUT). Our primary objective was to describe cerebral lesions on MRI in fetuses with severe anemia requiring IUT for B19V infection. Our secondary objective was to search for clinical and biological characteristics associated with the occurrence of such lesions. We performed a retrospective review of data on fetuses infected with B19V and requiring at least one IUT between 2005 and 2016. Fetuses with abnormal cerebral MRI results in the 3rd trimester were compared to those with normal MRI results. Of 34 transfused fetuses, 26 children were born at full term. Five intrauterine fetal deaths, 1 neonatal death, and 2 terminations of pregnancy occurred. Cerebral anomalies were observed in 7/27 fetuses on MRI, including cerebellar hemorrhage or a small cerebellum. Only viral load in fetal blood appeared to be associated with brain lesions (11.5 log10 copies/mL [10.5-12.5] in case of abnormal MRI results vs. 9.5 log10 copies/mL [7.8-10.0]; p = 0.05). Among the fetuses transfused for...Continue Reading

Citations

Oct 16, 2018·Minerva ginecologica·Pedro S Argoti, Giancarlo Mari
Oct 20, 2020·Frontiers in Immunology·Alexander OschwaldDaniel Erny
Dec 1, 2020·Prenatal Diagnosis·Katie MckinnonLatha Srinivasan
May 9, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Elka MillerThierry A G M Huisman
Dec 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Josepheen De Asis-CruzCatherine Limperopoulos

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