PMID: 2108117Feb 1, 1990Paper

Fetal breathing, sleep state, and cardiovascular responses to adenosine in sheep

Journal of Applied Physiology
B J Koos, K Matsuda

Abstract

The possibility that adenosine mediates hypoxic inhibition of fetal breathing and eye movements was tested in nine chronically catheterized fetal sheep (0.8 term). Intracarotid infusion of adenosine (0.25 +/- 0.03 mg.min-1.kg-1) for 1 h to the fetus increased heart rate and hemoglobin concentration but did not significantly affect mean arterial pressure or blood gases. As with hypoxia, adenosine decreased the incidence of rapid eye movements by 55% and the incidence of breathing by 77% without significantly affecting the incidence of low-voltage electrocortical activity. However, with longer (9 h) administration, the incidence of breathing and eye movements returned to normal during the adenosine infusion. Intravenous infusion of theophylline, an adenosine receptor antagonist, prevented most of the reduction in the incidence of breathing and eye movements normally seen during severe hypoxia (delta arterial PO2 = -10 Torr). It is concluded that 1) adenosine likely depresses fetal breathing and eye movements during hypoxia and 2) downregulation of adenosine receptors may contribute to the adaptation of breathing and eye movements during prolonged hypoxia.

Citations

May 20, 1998·Journal of Neurophysiology·B J KoosL Kruger
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·B J Koos, T Maeda
Apr 6, 2007·New Zealand Veterinary Journal·D J Mellor, T J Diesch
Mar 3, 2015·Basic & Clinical Pharmacology & Toxicology·Barent DuBoisSonnet S Jonker
Sep 17, 2002·The Journal of Physiology·Arlin B BloodGordon G Power
Jun 16, 2001·Journal of Applied Physiology·B J KoosC Jan
Jan 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takatsugu Maeda, Brian J Koos
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J Koos
Dec 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J KoosFanor Bohorquez
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Jun 11, 1999·The American Journal of Physiology·A Chau, B J Koos
Feb 12, 1998·The American Journal of Physiology·B J Koos, A Chau
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J KoosL Kruger
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M Bissonnette
Nov 24, 2001·Brain Research. Developmental Brain Research·J L MorrisonW Riggs
May 8, 1992·Brain Research·B J KoosW Doany
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alan D Bocking
Nov 5, 2005·Brain Research. Brain Research Reviews·David J MellorLaura Bennet
Aug 16, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·S M K BuckleyC Coutelle

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