PMID: 8311587Feb 1, 1994Paper

Fetal cardiac bypass: improved placental function with moderately high flow rates

The Annals of Thoracic Surgery
J A HawkinsW A Gay

Abstract

Prenatal correction of certain cardiac lesions with a poor prognosis may have advantages over postnatal repair. For this to be done, safe and effective support of the fetal circulation must be devised. Studies involving fetal cardiac bypass have demonstrated progressive fetal hypoxemia, hypercapnia, and acidosis, indicating placental dysfunction. We performed fetal cardiac bypass in 18 fetal lambs (126 to 140 days' gestation) to assess the effect of flow rate on fetal oxygenation and metabolism and function of the placenta as an in vivo oxygenator. Fetal cardiac bypass was done for a 30-minute study period at normothermia in all fetuses. During the study period the fetal aorta was cross-clamped and cold cardioplegia was administered to the heart so there was no fetal cardiac contribution to systemic output. Nine fetuses underwent studies at low flow rates (109 +/- 20 mL.kg-1.min-1) and 9 at higher flow rates (324 +/- 93 mL.kg-1.min-1). At the lower flow rate, mean aortic pressure, arterial pH, and oxygen tension decreased whereas carbon dioxide tension and lactate levels increased when compared with prebypass levels. At the higher flow rate mean aortic pressure, pH, oxygen tension, carbon dioxide tension, and lactate levels rem...Continue Reading

References

May 1, 1991·British Heart Journal·D MaxwellM J Tynan
Dec 1, 1986·Journal of the American College of Cardiology·R J CarpenterH T Engelhardt
Oct 1, 1982·The Annals of Thoracic Surgery·K TurleyP A Ebert

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Citations

May 13, 1999·The Annals of Thoracic Surgery·H F TrippJ P Coyle
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Marjan JahangiriJames Clark
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Adriano CarottiRoberto M Di Donato
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·G SatomiS Ishikawa
Mar 30, 2016·International Journal of Obstetric Anesthesia·D C MandelJ I Iruretagoyena
Feb 1, 1994·The Annals of Thoracic Surgery·F L Hanley
Mar 5, 2009·The Journal of Thoracic and Cardiovascular Surgery·R Scott BakerPirooz Eghtesady
Jan 6, 2005·The Journal of Thoracic and Cardiovascular Surgery·Akio IkaiV Mohan Reddy
May 30, 1998·The Journal of Thoracic and Cardiovascular Surgery·R S Assad, F L Hanley
Apr 30, 2008·The Annals of Thoracic Surgery·Christopher T LamPirooz Eghtesady
Sep 28, 2010·The Annals of Thoracic Surgery·Orlando PetrucciPirooz Eghtesady
Sep 5, 2012·The Journal of Thoracic and Cardiovascular Surgery·Vinod A SebastianV Mohan Reddy
Jul 26, 2011·The Journal of Thoracic and Cardiovascular Surgery·Xiao-bing LiuJian Zhuang
Dec 22, 2005·The Annals of Thoracic Surgery·Pirooz EghtesadyPeter Manning
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jingchun WuHarvey S Borovetz
May 29, 2021·Anesthesiology·Marie-Louise Meng, Katherine W Arendt

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