PMID: 8311587Feb 1, 1994Paper

Fetal cardiac bypass: improved placental function with moderately high flow rates

The Annals of Thoracic Surgery
J A HawkinsW A Gay


Prenatal correction of certain cardiac lesions with a poor prognosis may have advantages over postnatal repair. For this to be done, safe and effective support of the fetal circulation must be devised. Studies involving fetal cardiac bypass have demonstrated progressive fetal hypoxemia, hypercapnia, and acidosis, indicating placental dysfunction. We performed fetal cardiac bypass in 18 fetal lambs (126 to 140 days' gestation) to assess the effect of flow rate on fetal oxygenation and metabolism and function of the placenta as an in vivo oxygenator. Fetal cardiac bypass was done for a 30-minute study period at normothermia in all fetuses. During the study period the fetal aorta was cross-clamped and cold cardioplegia was administered to the heart so there was no fetal cardiac contribution to systemic output. Nine fetuses underwent studies at low flow rates (109 +/- 20 and 9 at higher flow rates (324 +/- 93 At the lower flow rate, mean aortic pressure, arterial pH, and oxygen tension decreased whereas carbon dioxide tension and lactate levels increased when compared with prebypass levels. At the higher flow rate mean aortic pressure, pH, oxygen tension, carbon dioxide tension, and lactate levels rem...Continue Reading


May 1, 1991·British Heart Journal·D MaxwellM J Tynan
Dec 1, 1986·Journal of the American College of Cardiology·R J CarpenterH T Engelhardt
Oct 1, 1982·The Annals of Thoracic Surgery·K TurleyP A Ebert

❮ Previous
Next ❯


May 13, 1999·The Annals of Thoracic Surgery·H F TrippJ P Coyle
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Marjan JahangiriJames Clark
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Adriano CarottiRoberto M Di Donato
Dec 12, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·G SatomiS Ishikawa
Mar 30, 2016·International Journal of Obstetric Anesthesia·D C MandelJ I Iruretagoyena
Feb 1, 1994·The Annals of Thoracic Surgery·F L Hanley
Mar 5, 2009·The Journal of Thoracic and Cardiovascular Surgery·R Scott BakerPirooz Eghtesady
Jan 6, 2005·The Journal of Thoracic and Cardiovascular Surgery·Akio IkaiV Mohan Reddy
May 30, 1998·The Journal of Thoracic and Cardiovascular Surgery·R S Assad, F L Hanley
Apr 30, 2008·The Annals of Thoracic Surgery·Christopher T LamPirooz Eghtesady
Sep 28, 2010·The Annals of Thoracic Surgery·Orlando PetrucciPirooz Eghtesady
Sep 5, 2012·The Journal of Thoracic and Cardiovascular Surgery·Vinod A SebastianV Mohan Reddy
Jul 26, 2011·The Journal of Thoracic and Cardiovascular Surgery·Xiao-bing LiuJian Zhuang
Dec 22, 2005·The Annals of Thoracic Surgery·Pirooz EghtesadyPeter Manning
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jingchun WuHarvey S Borovetz
May 29, 2021·Anesthesiology·Marie-Louise Meng, Katherine W Arendt

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
Bradley S Allen
The Journal of Thoracic and Cardiovascular Surgery
V Mohan ReddyF L Hanley
Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Noriyuki MuraiTakao Imazeki
© 2021 Meta ULC. All rights reserved