Fetal cell microchimerism develops through the migration of fetus-derived cells to the maternal organs early after implantation

Journal of Reproductive Immunology
Rei SunamiShuji Hirata

Abstract

Fetus-derived cells are present in the blood and tissues of the maternal body over a long period of time, even after delivery, resulting in fetal cell microchimerism. The exact process by which fetal cells cross the placental barrier to enter the maternal circulation is unclear. The objective of this paper was to determine the time during pregnancy that fetal cells with multilineage potential migrate to the maternal organs. Wild type female mice were crossbred with male transgenic mice, expressing enhanced green fluorescent protein (EGFP). Total hysterectomies were performed at different time points of pregnancy. On day 60 after surgery, mice were injected with either streptozotocin (STZ) to induce insulin-dependent diabetes mellitus, or vehicle. Detection and quantification of fetal cells were then undertaken in a variety of maternal organs via fluorescent microscopy and quantitative PCR amplification of the gfp transgene. In vehicle control mice, fetal cells were detected only in the maternal bone marrow. However on day 30 after STZ injection, fetal cells were detected not only in bone marrow but also in the maternal pancreas, liver and kidney. Histological analysis showed differentiated fetal cells within the pancreatic acin...Continue Reading

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Citations

Jul 29, 2010·Molecular Human Reproduction·Eddy S M LeeNicholas M Fisk
Jan 8, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Rei SunamiShuji Hirata
Mar 11, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·J C WarningJ M Morris
Feb 26, 2013·Journal of Reproductive Immunology·E SeppanenK Khosrotehrani
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Apr 25, 2014·Current Opinion in Pediatrics·Cerine JeantyTippi C Mackenzie
Mar 9, 2019·Annual Review of Genomics and Human Genetics·Hing-Yuen Yeung, Calliope A Dendrou

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