PMID: 6622404Jul 1, 1983Paper

Fetal chromosome analysis: screening for chromosome disease?

Prenatal Diagnosis
J PhilipM Madsen


The aim of the study was to investigate the rationale of the current indications for fetal chromosome analysis. 5372 women had 5423 amniocentesis performed, this group constituting a consecutive sample at the chromosome laboratory, Rigshospitalet, Copenhagen from March 1973 to September 1980 (Group A + B). Pregnant women 35 years of age, women who previously had a chromosomally abnormal child, families with translocation carriers or other heritable chromosomal disease, families where the father was 50 years or more and women in families with a history of Down's syndrome (group A), were compared to women having amniocentesis, although considered not to have any increased risk of fetal chromosome abnormality (1390 pregnancies, group B). They were also compared with 750 consecutive pregnancies in women 25-34 years of age, in whom all heritable diseases were excluded (group C). The risk of unbalanced chromosome abnormality in group A (women with elevated risk) is significantly higher than in group B + C (women without elevated risk) (relative risk 2.4). Women with a known familial translocation and women 40 years or more have a relative risk of 5.7 of having an unbalanced chromosome abnormality compared with women without elevated ...Continue Reading


Mar 27, 1976·British Medical Journal·S Hagard, F A Carter
Nov 1, 1976·Annals of Human Genetics·M MikkelsenE Petersen
Jan 25, 1979·The New England Journal of Medicine·M S GolbusB D Hall
Sep 27, 1979·The New England Journal of Medicine·S HarlapF Pellegrin
Oct 29, 1977·British Medical Journal·J PhilipM Madsen
Sep 27, 1976·JAMA : the Journal of the American Medical Association
Dec 1, 1975·American Journal of Obstetrics and Gynecology·J BangJ Philip
Nov 1, 1972·American Journal of Obstetrics and Gynecology·J Bang, A Northeved
Sep 18, 1980·The New England Journal of Medicine·P S Gerald
Jan 1, 1980·Acta Obstetricia Et Gynecologica Scandinavica·E B Obel


Nov 1, 1985·Prenatal Diagnosis·E TerzianA C Turnbull
Mar 1, 1988·American Journal of Medical Genetics·M S VerpS Elias
Feb 1, 1985·Clinical Genetics·J Philip, C Lundsteen

Related Concepts

Congenital Abnormality
Abortion, Tubal
Amniotic Fluid Index
Autosome Abnormalities
Karyotype Determination Procedure
Antenatal Screening Procedures
Autosomal Chromosome Disorders

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