PMID: 7931884Oct 1, 1994Paper

Fetal cocaine exposure and neonatal bilirubinemia

The Journal of Pediatrics
R P WennbergA Maynard

Abstract

To assess the effect of fetal exposure to cocaine on neonatal serum bilirubin values, we compared 17 infants whose cocaine exposure was confirmed by urine toxicology studies, with no evidence of other drug exposure by history or urinalysis, with 31 sequentially born healthy term infants without evidence of maternal drug use. The mean (+/- SD) bilirubin concentration in control infants was 110 +/- 32 mumol/L (6.5 +/- 1.9 mg/dl) at 30.5 +/- 5.4 hours of age, compared with 55 +/- 26 mumol/L (3.2 +/- 1.5 mg/dl) at 30.8 +/- 5.3 hours in cocaine-exposed infants (p < 0.001). We also compared the abilities of cocaine and clofibrate, a known inducer of bilirubin uridine diphosphate-glucuronosyl transferase (BGT), to induce drug and bilirubin metabolizing pathways in young male Sprague-Dawley rats. Animals received drugs or saline solution for 7 days, and livers were assayed for cytochrome P-450, peroxisomal beta-oxidase, delta 5-3-ketosteroid isomerase (KSI), glutathione-S-transferase (GST), and BGT. Cocaine was a weak inducer of GST but a strong inducer of KSI, a member of the GST family of enzymes that is closely associated with bilirubin transport (ligandin) in liver, and a moderately strong inducer of BGT. Neither drug increased cyt...Continue Reading

References

Apr 19, 1976·Biochemical and Biophysical Research Communications·A M Benson, P Talalay
Apr 1, 1979·Clinical Pharmacology and Therapeutics·D J StewartW Kalow
Oct 1, 1987·The Journal of Pediatrics·A S Oro, S D Dixon
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B MannervikH Jörnvall
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Dec 6, 1973·The New England Journal of Medicine·C ZelsonM Casalino
Nov 1, 1972·The Journal of Pediatrics·G NathensonH McNamara

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Citations

Jul 1, 1997·Journal of Clinical Pharmacology·W L WestT S Hinds
Jun 16, 2012·Experimental Diabetes Research·Amanda S DyeRobert P Hoffman
Feb 1, 2005·Neurotoxicology and Teratology·Deborah A FrankHoward Cabral

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