Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia

Journal of Thrombosis and Haemostasis : JTH
D J FreemanI A Greer

Abstract

Pre-eclampsia is associated with increased placental debris circulating in maternal plasma. This study related placental debris to maternal markers of coagulation and endothelial activation in pre-eclampsia. Circulating fetal corticotrophin-releasing hormone (CRH) mRNA and phosphatidylserine (PS)-exposing microparticles were assayed in third trimester plasma from women with pre-eclampsia (n = 32) and controls (n = 32) matched for age, body mass index, parity, and gestational age at sampling. Markers of maternal hemostasis and endothelial function were assessed. Fetal CRH mRNA levels were higher in pre-eclampsia [mean 0.75 (SD 2.77) CRH/glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA ratio] than in control pregnancies [0.20 (0.74), P = 0.014]. PS-exposing microparticle levels were not different between the groups. Women with pre-eclampsia had higher levels of tissue factor pathway inhibitor (TFPI), prothrombin F(1+2) fragment (F(1+2)), factor XIIa, soluble vascular cell adhesion molecule 1, von Willebrand factor and plasminogen activator inhibitor 1 than controls. Fetal CRH mRNA correlated with TFPI in pre-eclampsia and control groups (r = 0.38, P = 0.031, and r = 0.37, P = 0.039, respectively). Fetal CRH mRNA correlated w...Continue Reading

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Citations

Mar 31, 2012·Journal of Thrombosis and Thrombolysis·Lara Carvalho GodoiLuci Maria Sant'Ana Dusse
Jan 1, 2014·Journal of Clinical Medicine·Antonio Farina
Jan 26, 2011·Thrombosis Research·Anat Aharon, Benjamin Brenner
Jul 1, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Aurélie RousseauPatrick Van Dreden
Feb 17, 2009·Thrombosis Research·Anat Aharon, Benjamin Brenner
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Sep 6, 2019·Pregnancy Hypertension·Elham EtesamiMohammadreza Zamanian

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