Fetal crown-rump length and estimation of gestational age in an ethnic Chinese population

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
D S SahotaT K Lau

Abstract

To develop a sonographic dating formula based on fetal crown-rump length (CRL) in a Hong Kong Chinese population, quantify its systematic prediction error and compare its performance with established dating formulae. This was a prospective observational study of women with a spontaneously conceived singleton pregnancy and a regular menstrual cycle in the preceding 12-month period. Ultrasound examinations were performed at gestational ages ranging from 6 to 15 + 6 weeks according to menstrual dates. The CRL of each fetus was measured three times, the mean of which was used to derive the best-fit fractional polynomial regression model for estimation of gestational age in relation to CRL. For each fetus, the menstrual age was compared to the gestational age calculated using three established dating formulae based on CRL measurement. The mean of the differences between estimated and menstrual age was calculated for each formula. Of the 394 subjects recruited one was excluded as the pregnancy resulted in intrauterine demise. The best-fit equation for the sonographic estimate of gestational age (GA, in days) from CRL (in mm) was GA = 26.643 + 7.822 x CRL(1/2)(R(2) = 0.96). The mean difference between menstrual age and the predicted g...Continue Reading

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