Fetal death persists through recurrent pregnancies in mice following Ljungan virus infection

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Annika SamsioeWilliam Klitz

Abstract

Laboratory mice infected with Ljungan virus (LV) early in pregnancy suffer from perinatal death. Here we investigate the persistence of that effect through the outcome of consecutive pregnancies in LV-infected mice. CD-1 mice were infected while pregnant and their adult female offspring were followed in parallel with uninfected control mice during repeated pregnancies. Three mating attempts resulted in two or three pregnancies per dam. The outcome of the last pregnancy was carefully monitored. Both the dams infected as adults and their adult female offspring suffered perinatal deaths during the last pregnancy which occurred approximately 6 months after the original LV exposure and acute infection. The non-infected control animals experienced no perinatal death. Perinatal death persists across recurrent pregnancies in this mouse model of LV infection, both in animals infected as adults and in females exposed to the virus in utero. This implies that LV persists in mice long after initial infection, and is maintained in a quiescent state but can remain pathogenic in later pregnancies.

References

Jan 1, 1985·American Journal of Obstetrics and Gynecology·R K FreemanT J Garite
Apr 1, 1994·Paediatric and Perinatal Epidemiology·R GreenwoodD Ashley
Sep 2, 2004·Obstetrics and Gynecology·Antonio E FriasRobert M Silver
Aug 9, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeBo Niklasson
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Jul 31, 2007·Paediatric and Perinatal Epidemiology·Puza P SharmaRussel S Kirby

Citations

May 15, 2012·Journal of Virological Methods·René KalliesMatthias Niedrig
Jan 13, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Annika SamsioeBo Niklasson
Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Henry F Krous, Neil E Langlois
Mar 20, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Lili ZhengHong Xin
Jul 18, 2018·Pediatric Diabetes·Åshild Olsen Faresjö, Johnny Ludvigsson

Related Concepts

Congenital Abnormality
Fetal Mummification
Fetal Structures
Picornaviridae Infections
Pregnancy Complications, Infectious
Pregnancy Outcome
Relapse
Parechovirus
Fetal Death
Laboratory mice

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