PMID: 6539747Jun 1, 1984Paper

Fetal effects on sexual behavior and aggression in young and old female mice treated with estrogen and testosterone

Hormones and Behavior
J P Rines, F S Vom Saal

Abstract

During fetal life female mice (Mus musculus) that develop between two male fetuses (2M females) have higher blood concentrations of testosterone than do females that do not develop next to a male fetus (0M females). In the first experiment reported here, sexual receptivity and sexual attractiveness to males were examined in young (5 month old) and old (17 month old) ovariectomized, estrogen- and progesterone-treated 0M and 2M female mice that were placed in like-age pairs with a male. Most males inseminated the 0M female prior to inseminating the 2M female regardless of age. In addition, 0M females were more likely to exhibit lordosis when mounted than were 2M females. When the same young females were 9 months of age and the old females were 21 months of age, they were treated with testosterone and again placed together in pairs along with a sexually receptive female. Young 2M females exhibited more aggression toward the testosterone-treated female partner, and also exhibited more mounting of the receptive female, than did young 0M females. But, both old 0M and old 2M females were highly aggressive and exhibited mounting. An increase in sensitivity to the effects of testosterone on behavior thus occurs during aging in 0M female...Continue Reading

References

Jan 1, 1979·Neuroscience and Biobehavioral Reviews·M J Baum
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Citations

May 1, 1992·Physiology & Behavior·A Cologer-CliffordB M Jubilan
Apr 1, 1992·Physiology & Behavior·B M Jubilan, J G Nyby
Dec 14, 2002·Neuroscience and Biobehavioral Reviews·Bryce C Ryan, John G Vandenbergh
Mar 7, 2003·Behavioral Neuroscience·Elka M Scordalakes, Emilie F Rissman
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Virpi LummaaAndrew F Russell
May 12, 2010·Frontiers in Neuroendocrinology·P J BonthuisE F Rissman
Jan 19, 2012·Physiology & Behavior·Oxána BánszegiVilmos Altbäcker
Apr 25, 2001·Developmental Psychobiology·J L ZehrM K McClintock
Mar 21, 2018·International Journal of Toxicology·Siriporn Chamniansawat, Chattraporn Sawatdiyaphanon
Dec 1, 1995·British Journal of Obstetrics and Gynaecology·K Y LeungS Bower
Jul 24, 2021·Evolutionary Applications·Natalie L Dinsdale, Bernard J Crespi

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