Fetal endothelial and mesenchymal progenitors from the human term placenta: potency and clinical potential

Stem Cells Translational Medicine
A ShafieeJ Patel

Abstract

Since the isolation of fetal stem cell populations from perinatal tissues, such as umbilical cord blood and placenta, interest has been growing in understanding their greater plasticity compared with adult stem cells and exploring their potential in regenerative medicine. The phenomenon of fetal microchimerism (FMC) naturally occurring during pregnancy through the transfer of fetal stem/progenitor cells to maternal blood and tissues has been integral in developing this dogma. Specifically, microchimeric mesenchymal stem cells and endothelial progenitors of fetal origin have now demonstrated a capacity for tissue repair in the maternal host. However, the use of similar fetal stem cells in therapy has been significantly hampered by the availability of clinically relevant cell numbers and/or contamination with cells of maternal origin, particularly when using the chorionic and decidual placenta. In the present prospective review, we highlight the importance of FMC to the field of fetal stem cell biology and issues of maternal contamination from perinatal tissues and discuss specific isolation strategies to overcome these translational obstacles.

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Citations

Jul 7, 2016·Stem Cells Translational Medicine·Jatin PatelKiarash Khosrotehrani
Apr 19, 2017·Stem Cells and Development·Juan-Juan LiZhong-Chao Han
Feb 7, 2018·Stem Cell Research & Therapy·Mónica S Ventura FerreiraSabine Neuss
Aug 22, 2020·Stem Cells Translational Medicine·Abbas ShafieeJason Brown
Sep 6, 2017·Asian Pacific Journal of Tropical Medicine·Baburajan Radha, Gnanaraj Muniraj
Sep 27, 2020·Life Sciences·Somaye SadeghiSeyed Mahmoud Hashemi
Aug 28, 2021·Frontiers in Cell and Developmental Biology·Christopher StemGraça Almeida-Porada

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