Fetal exposure to 3,4-diaminopyridine in a pregnant woman with congenital myasthenia syndrome

The Annals of Pharmacotherapy
Ana Pelufo-PellicerJose L Poveda-Andrés

Abstract

To report a case of fetal exposure to pyridostigmine and 3,4-diaminopyridine (3,4-DAP) in a pregnant woman with congenital myasthenia syndrome (CMS). A 31-year-old woman with postsynaptic CMS, not genetically characterized, was being treated with pyridostigmine and 3,4-DAP. She decided to become pregnant, despite having been informed about the paucity of available information on the possible risks of these drugs for the fetus. The dose of pyridostigmine remained stable throughout the pregnancy (60 mg every 8 h), and the 3,4-DAP dose was adjusted according to the patient's level of fatigue (20 mg/day, with occasional additional doses of 5 mg). At 25 weeks' gestation, ultrasonography confirmed the presence of only one umbilical artery. The results of other tests were normal. At 38 weeks' gestation, a healthy male neonate was born. His APGAR scores were 9 and 10 at 1 and 5 minutes, respectively. Five months later, the infant was healthy and his pediatric progress had been uneventful. It was difficult to find information about the possible congenital defects related to the use of 3,4-DAP because it is a rarely used drug. This case attracted our interest because it is an uncommon disease, and we found no reports on the use of 3,4-DA...Continue Reading

References

Jul 1, 1993·Neuromuscular Disorders : NMD·J Dinger, B Prager
May 10, 2000·Neurology·C E Niesen, N S Shah
Feb 8, 2003·Prenatal Diagnosis·A S GornallJ C Konje
Apr 23, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·For-Way Lung, Po-Jen Chen
Nov 26, 2003·Neurology·Jana Midelfart HoffNils Erik Gilhus
Dec 23, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G RembouskosK H Nicolaides
Jan 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sandra PruckaElizabeth McPherson
Jul 2, 2004·Seminars in Neurology·C Michel Harper

❮ Previous
Next ❯

Citations

Jan 3, 2013·Annals of the New York Academy of Sciences·Tyler B TarrStephen D Meriney
Sep 20, 2019·Expert Review of Clinical Immunology·Shin J Oh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Arthritis and Rheumatism
Christina D ChambersOrganization of Teratology Information Specialists Collaborative Research Group
BJOG : an International Journal of Obstetrics and Gynaecology
HAPO Study Cooperative Research Group
BJOG : an International Journal of Obstetrics and Gynaecology
A EinarsonGideon Koren
© 2021 Meta ULC. All rights reserved