PMID: 15385828Sep 24, 2004Paper

Fetal exposure to alcohol as evidenced by fatty acid ethyl esters in meconium in the absence of maternal drinking history in pregnancy

Therapeutic Drug Monitoring
Daphne ChanGideon Koren

Abstract

The detection of fatty acid ethyl esters (FAEE) in neonatal meconium has been proposed as a novel screening method for intrauterine exposure to alcohol. We investigated the potential use of meconium FAEE screening in a high-risk neonatal population in the absence of maternal drinking history. One hundred forty-two meconium samples of neonates suspected of intrauterine illicit substance exposure and referred to the Motherisk Laboratory were analyzed for the existence of drugs by enzyme-linked immunosorbent assay (ELISA) and FAEE by gas chromatography-flame ionization detection (GC-FID). A positive FAEE test was previously defined as a cumulative measurement of 7 individual FAEE > or = 2 nmol/g. Seventy-one percent of the samples tested positive for at least 1 illicit drug, with cannabis being the most prevalent (52.3%). Fourteen percent of all samples tested positive for prenatal alcohol exposure, as evidenced by cumulative meconium FAEE > or = 2 nmol/g. Ethyl oleate, linoleate, palmitate, and arachidonate were detected most often and at the highest levels. At least 3 individual FAEE were detected in 95% of all positive samples, and none could be identified by the use of 1 selected FAEE. Significantly elevated levels of FAEE abo...Continue Reading

References

Nov 3, 1973·Lancet·K L Jones, D W Smith
Nov 1, 1994·General Hospital Psychiatry·D E Stewart, D Streiner
Feb 1, 1996·Alcoholism, Clinical and Experimental Research·M W Miller
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·C F BearerL T Singer
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·H M Barr, A P Streissguth
Jan 1, 2003·Clinical Chemistry·Christine MooreKaren Buchi
Feb 25, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·B Bar-OzG Koren
Oct 23, 2003·The Journal of Pediatrics·Cynthia F BearerAndrew S Cwik

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Citations

Jan 14, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Cleofina Bosco, Eugenia Diaz
Oct 6, 2012·Pediatric Clinics of North America·Kaitlyn Delano, Gideon Koren
Aug 18, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E SerorC Lejeune
Apr 26, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Larry Burd, Ryan Hofer
Dec 16, 2011·Alcoholism, Clinical and Experimental Research·Simona PichiniLuca Morini
Feb 12, 2014·Alcoholism, Clinical and Experimental Research·Ludmila N BakhirevaWilliam F Rayburn
May 7, 2014·BioMed Research International·Tamme W GoeckeJohannes Kornhuber
Aug 29, 2006·Neuroscience and Biobehavioral Reviews·Daniela L CapraraGideon Koren
May 22, 2016·Clinical Biochemistry·Natalie KummerChristophe P Stove
Jan 19, 2017·Alcoholism, Clinical and Experimental Research·Heidi BagerLene Bjerregaard
Nov 29, 2007·Therapeutic Drug Monitoring·Jaime LozanoSimona Pichini
Jan 18, 2015·Clinical Chemistry·Sarah K HimesUNKNOWN Prenatal Alcohol in SIDS and Stillbirth (PASS) Network
Jul 21, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Vivian KulagaGideon Koren
Mar 5, 2009·Therapeutic Drug Monitoring·Irene Zelner, Gideon Koren
Mar 28, 2008·Therapeutic Drug Monitoring·Oscar Garcia-AlgarSimona Pichini
Nov 20, 2020·Experimental Biology and Medicine·Charlie T ChengRonald L Thomas

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