Fetal exposure to ethanol: relationship between ethyl glucuronide in maternal hair during pregnancy and ethyl glucuronide in neonatal meconium

Clinical Chemistry and Laboratory Medicine : CCLM
Xavier JoyaSimona Pichini

Abstract

In recent years, fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG) in meconium emerged as reliable, direct biological markers for establishing gestational ethanol exposure. We investigated whether EtG in maternal hair measured during the three trimesters of pregnancy correlated with EtG and FAEEs in neonatal meconium. In a prospective sample of 80 mother-infant dyads from Barcelona (Spain), we measured EtG and FAEE in maternal hair segments and meconium samples using a validated UHPLC-MS/MS method. Fifty-eight (72.5%) women had EtG concentrations in the hair shafts >7 pg/mg in one or more pregnancy trimesters, and EtG and FAEEs in meconium samples were documented in 50 and 24 of their neonates, respectively. The best significant correlations (p<0.0001) were found between EtG concentration in the proximal 0-3 and 3-6 hair shaft segments corresponding to the last two pregnancy trimesters and EtG in neonatal meconium (ρ=0.609 and ρ=0.577, respectively). Using the combination of EtG in meconium ≥30 ng/g and a median of EtG >11 pg/mg in maternal hair during the second and third trimesters of pregnancy, prenatal ethanol exposure could be predicted with a sensitivity of 85.7% and specificity of 73.7%. This study provides evi...Continue Reading

References

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Citations

Feb 2, 2016·International Journal of Environmental Research and Public Health·Onni Niemelä
Jan 19, 2017·Alcoholism, Clinical and Experimental Research·Heidi BagerLene Bjerregaard
Nov 2, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A Bastons-ComptaO Garcia-Algar
Aug 4, 2018·Nutrients·Giorgia SebastianiOscar García-Algar
Mar 15, 2020·Drug Testing and Analysis·Alexander Müller, Stefanie Iwersen-Bergmann
Jan 20, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sara Jaffee
Mar 23, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Silvia Maya-EneroÓscar García-Algar
Aug 31, 2021·Anales De Pediatría·Silvia Maya-EneroÓscar García-Algar
Oct 13, 2021·Anales De Pediatría·Antonia RocaBernardino Barceló
Oct 13, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Antonia RocaBernardino Barceló
Sep 1, 2016·Pediatrics·Cheryl McQuireAlison Kemp

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