Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age.

Diabetes
Charbel Abi KhalilMichel Marre

Abstract

In animal studies, hyperglycemia during fetal development reduces nephron numbers. We tested whether this observation translates into renal dysfunction in humans by studying renal functional reserve in adult offspring exposed in utero to maternal type 1 diabetes. We compared 19 nondiabetic offspring of type 1 diabetic mothers with 18 offspring of type 1 diabetic fathers (control subjects). Glomerular filtration rate ((51)Cr-EDTA clearance), effective renal plasma flow ((123)I-hippurate clearance), mean arterial pressure, and renal vascular resistances were measured at baseline and during amino acid infusion, which mobilizes renal functional reserve. Offspring of type 1 diabetic mothers were similar to control subjects for age (median 27, range 18-41, years), sex, BMI (23.1 ± 3.7 kg/m(2)), and birth weight (3,288 ± 550 vs. 3,440 ± 489 g). During amino acid infusion, glomerular filtration rate and effective renal plasma flow increased less in offspring of type 1 diabetic mothers than in control subjects: from 103 ± 14 to 111 ± 17 ml/min (8 ± 13%) vs. from 108 ± 17 to 128 ± 23 ml/min (19 ± 7%, P = 0.009) and from 509 ± 58 to 536 ± 80 ml/min (5 ± 9%) vs. from 536 ± 114 to 620 ± 140 ml/min (16 ± 11%, P = 0.0035). Mean arterial press...Continue Reading

References

Aug 1, 1985·The Journal of Clinical Investigation·S AndersonB M Brenner
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
Oct 1, 1980·Journal of Clinical Ultrasound : JCU·E Lewis, W G Ritchie
Dec 1, 1980·Diabetes·N Freinkel
Mar 14, 1998·Diabetologia·H SackmannJ L Ader
Jan 10, 2003·The New England Journal of Medicine·Gunhild KellerKerstin Amann
May 20, 2003·Kidney International·Michael HughsonJohn F Bertram
Jun 6, 2003·Lancet·Eugène SobngwiJean-François Gautier
Jul 15, 2005·Kidney International. Supplement·Valerie A Luyckx, Barry M Brenner
Dec 24, 2005·Kidney International·W M BernhardtK-U Eckardt
Jul 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Lila-Sabrina FetitaJean-François Gautier
Jan 27, 2007·Circulation Research·Irina BogdarinaAdrian J L Clark
Aug 22, 2008·Journal of the American Society of Nephrology : JASN·Gregory R Dressler
May 7, 2009·The Journal of Clinical Endocrinology and Metabolism·Tine D ClausenPeter Damm

❮ Previous
Next ❯

Citations

Feb 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jörg DötschKerstin Amann
Jul 6, 2014·Journal of Developmental Origins of Health and Disease·B CappucciniG Di Renzo
Oct 25, 2011·Journal of the American Society of Nephrology : JASN·Marpadga A Reddy, Rama Natarajan
Dec 5, 2013·Diabetes Research and Clinical Practice·T TamayoW Rathmann
Feb 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jennifer R CharltonJ Bryan Carmody
Dec 11, 2014·The Journal of Antimicrobial Chemotherapy·Pedro Henrique França GoisAntonio Carlos Seguro
Oct 17, 2015·The Journal of Pediatrics·Elizabeth A C SellersHeather J Dean
Oct 3, 2015·European Journal of Endocrinology·Baz BazJean-François Gautier
Oct 16, 2015·Current Diabetes Reports·Jennifer PasquierCharbel Abi Khalil
Jan 21, 2015·Nature Reviews. Nephrology·Valerie A Luyckx, Barry M Brenner
Mar 21, 2017·Nephron·UNKNOWN Low Birth Weight and Nephron Number Working Group
Apr 25, 2018·Journal of the Endocrine Society·Jean-François GautierFranck Mauvais-Jarvis
Nov 26, 2015·Journal of Hypertension·Empar Lurbe, Julie R Ingelfinger
Mar 11, 2016·Current Opinion in Pediatrics·Jörg DötschKai D Nüsken
Oct 7, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Valerie A Luyckx, Barry M Brenner
Oct 9, 2019·Endocrinology, Diabetes & Metabolism·Stacey HokkeLuise A Cullen-McEwen
Apr 13, 2021·American Journal of Physiology. Renal Physiology·Meredith B CobbMichael R Garrett

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.