Fetal exposure to paternal smoking and semen quality in the adult son.

Andrology
Katia Keglberg HaervigSandra Søgaard Tøttenborg

Abstract

The negative impact of maternal smoking during pregnancy on offspring semen quality is well established. Less is known about the impact of paternal smoking. We estimated differences in semen parameters and testicle size according to paternal smoking in 772 adult sons of women enrolled in the Danish National Birth Cohort when pregnant. Parents' smoking was reported around gestational week 16, and analyses were adjusted for parents' ages at conception, maternal pre-pregnancy body mass index, maternal alcohol and caffeine intake, family occupational status, ejaculatory abstinence time, clinic of semen analysis, and season. Sons of smoking fathers and non-smoking mothers had a 10% (95% confidence interval: -24%, 7%) lower semen concentration and 11% (95% confidence interval: -27%, 8%) lower sperm count than sons of non-smoking parents. Having two smoking parents was associated with 19% reduction in sperm count (95% confidence interval: -37%, 3%). Paternal smoking was not associated with volume, motility, or morphology. Adjusting for maternal smoking, paternal smoking was associated with a 26% increased risk of small testicular volume (95% confidence interval: 0.89, 1.78). Exclusion of sons with a history of testicular cancer, chemo...Continue Reading

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Citations

Oct 17, 2020·Environmental and Molecular Mutagenesis·Abigail P BlineUNKNOWN Workshop Presenters
Mar 7, 2021·International Journal of Environmental Research and Public Health·Thea Emily BensonGunnar Toft
Oct 2, 2021·Journal of Autism and Developmental Disorders·Jill EscherVictor G Corces

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