Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome.

Disease Models & Mechanisms
Simon J TunsterRosalind M John

Abstract

Beckwith-Wiedemann syndrome (BWS) is a complex imprinting disorder involving fetal overgrowth and placentomegaly, and is associated with a variety of genetic and epigenetic mutations affecting the expression of imprinted genes on human chromosome 11p15.5. Most BWS cases are linked to loss of methylation at the imprint control region 2 (ICR2) within this domain, which in mice regulates the silencing of several maternally expressed imprinted genes. Modelling this disorder in mice is confounded by the unique embryonic requirement for Ascl2, which is imprinted in mice but not in humans. To overcome this issue, we generated a novel model combining a truncation of distal chromosome 7 allele (DelTel7) with transgenic rescue of Ascl2 expression. This novel model recapitulated placentomegaly associated with BWS, but did not lead to fetal overgrowth.

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Citations

Feb 19, 2020·Human Reproduction Update·Miriam ElbrachtThomas Eggermann
May 20, 2020·Disease Models & Mechanisms·Suhee Chang, Marisa S Bartolomei

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

DelTel

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Beckwith-Wiedemann syndrome

Beckwith-Wiedemann syndrome is an imprinting disorder characterized by overgrowth, congenital malformations and predisposition to tumors. Discover the latest research on Beckwith-Wiedemann Syndrome here.