Fetal growth retardation and increased placental weight in the spontaneously hypertensive rat

Reproduction, Fertility, and Development
B M Johnston

Abstract

Epidemiological studies have linked low birth weight and increased placental weight with increased risk of hypertension in adult life. It has been proposed that the cardiovascular changes which lead to hypertension are initiated in utero by processes associated with intrauterine growth retardation. The alternative possibility, that hypertension may result from genetic influences which also determine fetal and placental size, has had less support because birth weight is not determined genetically in humans. However, in the spontaneously hypertensive rat (SHR) essential hypertension is known to be transmitted genetically. Fetal and placental weights were, therefore, measured at Day 20 gestation in SHRs and compared with those in the normotensive Wistar Kyoto (WKY) control strain. Fetal weight (1.93 +/- 0.04 g) was significantly (P < 0.001) reduced in SHRs compared with WKY fetuses (2.23 +/- 0.01 g) but placental weight was heavier (P < 0.001) in SHRs (0.347 +/- 0.005 g) than in WKY rats (0.300 +/- 0.006 g) although litter size was not different. As expected, maternal blood pressure recorded under 1% halothane anaesthesia was higher (126 +/- 2.7 mm Hg) in SHR than WKY rats (100 +/- 2.1 mm Hg; 1 mm Hg = 133 Pa). In addition the con...Continue Reading

Citations

Jan 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B M Altura, B T Altura
Nov 3, 2005·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Haim BassanShaul Harel
Jun 12, 2012·PloS One·Anokhi Ali KhanMarjo-Riitta Järvelin
May 18, 2013·American Journal of Public Health·Amelia L GreinerKatherine Clegg Smith
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