PMID: 9548180Apr 21, 1998Paper

Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels

Placenta
M LuckasJ Meekins

Abstract

Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was that the similar placental pathological changes shared by unexplained normotensive IUGR and pre-eclampsia would be reflected by elevated maternal serum hCG levels in the second trimester. Normotensive women delivering unexplained singleton growth retarded infants were identified (n=43) and their second trimester hCG levels, taken as part of antenatal screening for Down's syndrome, were obtained. These were compared with a control group of 625 women, and a group of 48 women who subsequently developed pre-eclampsia. There was no significant difference in the hCG levels expressed as multiples of the median (MOM) between the women who delivered growth retarded fetuses (median MOM 0.96) and the control group (median MOM 0.97). The levels of hCG in the women who subsequently developed pre-eclampsia were significantly higher (median MOM 1.3, P=0.008). There were no significant differences in AFP levels in the three groups; h...Continue Reading

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References

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Citations

Dec 16, 2003·Obstetrics and Gynecology·José L BarthaRafael Comino-Delgado
Feb 13, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Reli HershkovitzMoshe Mazor
Jul 11, 2007·Prenatal Diagnosis·Ramesh GanapathyPaul Bassett
Apr 29, 2006·American Journal of Obstetrics and Gynecology·Dena TownerDina El Kady
Oct 6, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reli HershkovitzMoshe Mazor
Aug 17, 2012·The Cochrane Database of Systematic Reviews·James P Neilson
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia

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