PMID: 7937231Jul 1, 1994Paper

Fetal heart block: a new experimental model to assess fetal pacing

Pacing and Clinical Electrophysiology : PACE
R S AssadA D Jatene


Epicardial fetal pacing via thoracotomy has the potential of being a safer and more reliable procedure to treat congenital complete heart block (CHB) associated with fetal hydrops refractory to medical therapy. To assess the acute electrophysiological characteristics of two ventricular epicardial leads, a new experimental model of fetal heart block induced by cryosurgical ablation of the AV node without the need for fetal cardiac bypass was performed in 12 pregnant ewes at 110-115 days gestation. A modified screw-in lead (1 1/2 turns) was used in six fetal lambs and a stitch-on lead in the other six lambs. CHB was achieved in 100% of the fetal lambs, with no ventricular escape rate noticed in any of the lambs. The acute stimulation thresholds were consistently low for both leads, with lower values for the screw-in lead at pulse duration below 0.9 msec (P < 0.03). Current measured at voltage threshold with pulse width below 0.5 msec was lower for the screw-in lead (P < 0.048). Stimulation resistance, measured during constant-voltage pacing, was not statistically different between the two leads (441.8 +/- 13.7 omega for the screw-in lead vs 480.2 +/- 59.2 omega for the stitch-on lead). No significant differences (P > 0.20) were f...Continue Reading


May 1, 1991·Journal of the American College of Cardiology·K G SchmidtJ A Copel
Jun 1, 1990·Journal of Pediatric Surgery·T M CrombleholmeE D Verrier
Nov 1, 1987·Pacing and Clinical Electrophysiology : PACE·D ScagliottiK C Pringle
Dec 1, 1988·British Heart Journal·M V MachadoL D Allan
Apr 1, 1988·The Journal of Pediatrics·F Z BiermanJ Driscoll
Dec 1, 1986·Journal of the American College of Cardiology·R J CarpenterH T Engelhardt
May 1, 1985·Journal of Clinical Ultrasound : JCU·J C HuhtaE Abinader
Jan 1, 1985·Clinical Cardiology·D C CrowleyA Rosenthal
Sep 1, 1971·Stroke; a Journal of Cerebral Circulation·I S CooperK Wisniewska
Sep 1, 1983·British Heart Journal·L D AllanM Tynan
Sep 1, 1984·Clinical Cardiology·L D AllanM Tynan
Jan 1, 1984·Biology of the Neonate·B W GoetzmanA M Rudolph
Jul 1, 1981·Progress in Cardiovascular Diseases·S S BaroldR A Heinle
Oct 1, 1982·British Journal of Obstetrics and Gynaecology·J W WladimiroffJ S McGhie
Sep 1, 1981·British Journal of Obstetrics and Gynaecology·J W Wladimiroff, J McGhie
Feb 1, 1951·Circulation·C B TAYLORG M HASS

❮ Previous
Next ❯


Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Renato S AssadSérgio A Oliveira
May 24, 2000·Progress in Pediatric Cardiology·J F Strasburger
Mar 27, 2001·Clinics in Perinatology·R E Tanel, L A Rhodes
May 17, 2002·American Journal of Obstetrics and Gynecology· AyustawatiIkuo Sato
Apr 29, 2003·Pacing and Clinical Electrophysiology : PACE·Joseph Dell'OrfanoMarc Ovadia

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.