PMID: 3322047Dec 1, 1987Paper

Fetal heart rate, arterial pressure, and blood volume responses to cortisol infusion

The American Journal of Physiology
C E WoodR A Brace

Abstract

The purpose of this study was to determine whether physiological amounts of cortisol affect the fetal cardiovascular system. Cortisol (4 micrograms/min) or the vehicle was infused intravenously for 5 h into six chronically catheterized sheep fetuses at 127-143 days gestation (term = 145-150 days). In the cortisol-infused animals, plasma cortisol concentration increased from 2.0 +/- 0.6 (SE) to 8.3 +/- 0.9 ng/ml. There was a concomitant decrease in fetal heart rate of 38 beats/min (P less than 1 X 10(-6)) and an increase in arterial pressure. Estimated blood volume decreased by 6% in the cortisol-infused fetuses compared with the vehicle-infused animals (P less than 1 X 10(-4]. In addition, plasma norepinephrine and epinephrine concentrations decreased to 70% of control at the end of the 5-h cortisol infusion, whereas plasma renin concentration decreased to 34% of control. The simultaneous increase in fetal arterial pressure and decrease in estimated blood volume suggest that fetal vascular resistance increased, whereas vascular compliance and/or nonstressed vascular volume decreased. However, this does not appear to be mediated by increases in circulating vasoconstrictor hormone concentrations or increased sympathetic tone. Thu...Continue Reading

Citations

Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Daliao XiaoLubo Zhang
Mar 26, 2005·The Journal of Physiology·Dino A GiussaniAbigail L Fowden
Mar 16, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keiichi AdachiCharles A Ducsay
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M G ErvinA H Jobe
Jul 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles E WoodMaureen Keller-Wood

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