Jul 1, 1989

Fetal hemoglobin heterogeneity in Brazilian newborns and beta-thalassemia homozygotes

Haematologica
M A Zago

Abstract

The gamma chain composition of HbF in 37 beta-thalassemia homozygotes and 85 unselected newborn babies from Brazil was studied by high performance liquid chromatography (HPLC). The G gamma value of 59.5 +/- 7.5% (mean +/- SD) obtained for the beta-thalassemia homozygotes was significantly lower than the newborn value of 71.2 +/- 4.2%. The A gamma T gene frequency was 0.159 for the newborns and 0.454 for the thalassemia homozygotes. The A gamma T gene occurred both in chromosomes bearing the beta(0)-thalassemia gene and those with the beta(+)-thalassemia gene.

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Mentioned in this Paper

T gene
Fetal Hemoglobin
High Pressure Liquid Chromatography Procedure
Globin
Chromosomes
Thalassemia
Fetal Hemoglobin Determination
Beta Thalassemia

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