Fetal hemoglobin in sickle cell anemia: relationship to erythrocyte adhesion markers and adhesion.

Blood
B N SettyM J Stuart

Abstract

To assess whether fetal hemoglobin (HbF) modulates the adhesion of sickle erythrocytes to endothelium, children with homozygous sickle cell anemia (SS disease) were studied, using this physiologically crucial period to evaluate the relationships between HbF and the major erythrocyte adhesion markers. The mean level of CD36(+) erythrocytes was 2.59% +/- 2.15% (+/- SD, n = 40) with an inverse relationship between CD36 positivity and F cells (R = -0.76, P < .000 00 002). In univariate analyses, significant correlations with various hematologic parameters and age were noted. Multiple regression analyses, however, revealed a relationship solely with F cells. Minimal levels of very late activation antigen-4(+) (VLA4(+)) erythrocytes (0.31% +/- 0.45%, n = 40) with relationships similar to those noted for CD36(+) cells were also observed. The subpopulation of strongly adhesive stress reticulocytes was further assessed, using CD71 as their marker. The mean level of CD71(+) erythrocytes was 5.81% +/- 4.21%, with statistical correlates in univariate and multivariate analyses similar to those discussed above. When adhesion ratios were evaluated, inverse correlations were noted between basal and plasma-induced adhesion and F-cell numbers (R...Continue Reading

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References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R L NagelK Matsutomo
Apr 12, 1990·The New England Journal of Medicine·G P RodgersA W Nienhuis
Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Oct 1, 1989·American Journal of Hematology·S K BallasS Charache
Sep 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M F GrahamH P Ehrlich
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BalletR Infante
Feb 1, 1980·The Journal of Cell Biology·B M GlaserA Fenselau
May 1, 1980·The New England Journal of Medicine·R P HebbelM H Steinberg
May 1, 1994·British Journal of Haematology·S J ThorpeE R Huehns
Apr 1, 1996·The Journal of Laboratory and Clinical Medicine·P V Browne, R P Hebbel
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
Dec 3, 1999·British Journal of Haematology·C ClosseM R Boisseau

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Citations

Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J P Cartron, Y Colin
Oct 3, 2002·Annual Review of Medicine·Martin H Steinberg, Carlo Brugnara
Dec 24, 2013·Antioxidants & Redox Signaling·Florian LangMichael Föller
Jul 12, 2002·American Journal of Hematology·A D AdekileA Moosa
Jul 4, 2007·Expert Review of Cardiovascular Therapy·Gregory BarshteinSaul Yedgar
May 9, 2002·Expert Opinion on Investigational Drugs·Martin H Steinberg, Carlo Brugnara
Mar 5, 2014·Hematology/oncology Clinics of North America·Zahra Pakbaz, Ted Wun
Oct 23, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Suhita Gayen Betal, B N Yamaja Setty
Nov 25, 2014·Scientific Reports·Yunus AlapanUmut A Gurkan
Oct 18, 2005·British Journal of Haematology·Nancy J WanderseeCheryl A Hillery
Jul 25, 2003·American Journal of Hematology·R MaroufA D Adekile
Nov 10, 2006·American Journal of Hematology·Eileen M FinneganGilda A Barabino
Apr 12, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Yunus AlapanUmut A Gurkan
Feb 18, 2004·Hematology·Fatemeh TavakkoliElliott Perlin
Mar 31, 2015·BioMed Research International·Elisabeth Lang, Florian Lang
Feb 20, 2014·PloS One·Renata Proença-FerreiraNicola Conran
Oct 28, 2016·Expert Review of Medical Devices·Yunus AlapanUmut A Gurkan
Nov 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Johnson HaynesTroy Stevens

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