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Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice

The Journal of Clinical Investigation

Jan 12, 1999

J L ClementsGary A Koretzky

Abstract

The adapter protein SLP-76 is expressed in T lymphocytes and hematopoietic cells of the myeloid lineage, and is known to be a substrate of the protein tyrosine kinases that are activated after ligation of the T-cell antigen receptor. Transient overexpression of SLP-76 in a T-cell line p...read more

Mentioned in this Paper

Platelet Dysfunction
Biochemical Pathway
Fetal Structures
T-Lymphocyte
LCP2 wt Allele
Megakaryocytes
Intracellular Signaling Proteins
Hormone Receptors, Cell Surface
Phospholipase C gamma D
Receptor-Mediated Signal Transduction
Paper Details
References
  • References30
  • Citations103
123
  • References30
  • Citations103
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Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice

The Journal of Clinical Investigation

Jan 12, 1999

J L ClementsGary A Koretzky

PMID: 9884330

DOI: 10.1172/jci5317

Abstract

The adapter protein SLP-76 is expressed in T lymphocytes and hematopoietic cells of the myeloid lineage, and is known to be a substrate of the protein tyrosine kinases that are activated after ligation of the T-cell antigen receptor. Transient overexpression of SLP-76 in a T-cell line p...read more

Mentioned in this Paper

Platelet Dysfunction
Biochemical Pathway
Fetal Structures
T-Lymphocyte
LCP2 wt Allele
Megakaryocytes
Intracellular Signaling Proteins
Hormone Receptors, Cell Surface
Phospholipase C gamma D
Receptor-Mediated Signal Transduction

Feeds With Similar Papers

Phosphorylation

Phosphorylation is the attachment of a phosphoryl group, which is often provided by ATP, to a protein by a specific type of enzyme called kinase. Discover the latest research on phosphorylation here.

T cell Differentiation

Differentiation of naive T cells into effector cells ensures optimal protection against pathogens and the development of immunological memory. Here is the latest research.

Related Papers

Paper Details
References
  • References30
  • Citations103
123
  • References30
  • Citations103
12345...

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