Fetal Intestinal Cell Growth as a Measure of the Comparative Biofunctionality of Human Milk and Infant Formulas: An In Vitro Study

Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine
Nutkridta PongsakulSomchai Chutipongtanate

Abstract

Infant formulas are produced to resemble human milk (HM) and to provide adequate energy and appropriate nutritional components for suitability of infant growth and development, some of which are customized for specific medical conditions. However, it has remained unclear whether formulas contain any biofunctionality equivalent to HM, particularly fetal intestinal cell growth promotion. To evaluate the biofunctionality in HM and various formulas by using an in vitro fetal intestinal cell growth assay. Nine specimens of HM collected from 9 milk donors and 16 formulas consisting of 5 regular formulas (RFs), 2 preterm formulas (PFs), 2 partial hydrolysate formulas (PHFs), 3 extensive hydrolysate formulas (EHFs), 2 amino acid formulas (AAFs), and 2 soy protein formulas (SPFs) were included. Fetal intestinal cell growth assay was performed in six replicates per milk specimen. Biofunctionality of HM digest (HMD) derived from in vitro tryptic digestion of HM was also examined. Statistical analysis was performed by ANOVA with post-hoc Tukey's Honestly Significant Difference test. The fetal intestinal cell growth-promoting activity of HM and formula groups were sorted from the highest as follows: HM, 192.8% ± 16.7%; AAF, 153.5% ± 17.8%; ...Continue Reading

References

Jul 31, 2007·Life Sciences·Yoshikazu KandaKeico Mashimo
Oct 5, 2007·Early Human Development·Josef Neu
Feb 27, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·S-L ChuangJ M Fell
Mar 19, 2008·Seminars in Perinatology·Rajalakshmi R NairBrad W Warner
Oct 16, 2009·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Stanley IpJoseph Lau
Mar 1, 2012·Pediatrics·UNKNOWN Section on Breastfeeding
Sep 6, 2012·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Arthur I Eidelman
Nov 28, 2012·Pediatric Clinics of North America·Olivia Ballard, Ardythe L Morrow
Mar 6, 2013·Journal of Paediatrics and Child Health·Bo Lönnerdal
Aug 2, 2013·Amino Acids·Ramesh M Ray, Leonard R Johnson
Feb 11, 2014·Dairy Science & Technology·Vassilios Raikos, Theodore Dassios
Jan 21, 2016·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Amy B HairSteven A Abrams
Oct 3, 2017·Journal of Pediatric Gastroenterology and Nutrition·Annet MaathuisSusann Bellmann
Feb 17, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Pasinee KanaprachSomchai Chutipongtanate

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