Fetal leptin influences birth weight in twins with discordant growth

Pediatric Research
S R SoorannaR Bajoria

Abstract

The objective of this study was to determine the plasma leptin concentrations in twin pregnancies in relation to chorionicity and discordant fetal growth. We studied 53 twin pregnancies of which 26 had growth discordance of > or =20% and 27 were concordant for growth (discordance of < or =10%). Paired maternal and fetal blood samples were obtained at birth. Plasma leptin concentrations were measured by RIA. In discordant monochorionic pregnancies, fetal plasma leptin concentrations in the intrauterine growth-restricted twins were lower than the co-twins with normal growth (mean difference, 3 ng/mL; 95% CI, 2.2 to 3.3 ng/mL; p < 0.001), whereas no such differences were present between concordant monochorionic twin pairs (mean difference, 0.1 ng/mL; 95% CI, -0.2 to 0.5 ng/mL; NS). Similarly, fetal plasma leptin concentrations in appropriate-for-gestational-age twins were higher than in the intrauterine growth-restricted twins of the discordant dichorionic pregnancies (mean difference, 2.4 ng/mL; 95% CI, 1.8 to 3.1 ng/mL; p < 0.001). No such differences were present between the concordant dichorionic twin pairs (mean difference, 0.2 ng/mL; 95% CI, -0.1 to 0.5 ng/mL; NS). Maternal plasma leptin concentrations were comparable among ...Continue Reading

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Citations

Nov 6, 2007·The British Journal of Nutrition·Michael L Power, Jay Schulkin
Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Jun 11, 2004·Journal of Perinatal Medicine·Ozgür OktemZehra Nese Kavak
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Aug 11, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sorina Grisaru-GranovskyDeborah Elstein
Oct 29, 2015·Hormone Molecular Biology and Clinical Investigation·Esther Dos SantosMarie-Noëlle Dieudonné
Feb 23, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Christina M HultmanPaul Lichtenstein
May 15, 2010·Biochemical and Biophysical Research Communications·Antonio Pérez-PérezVíctor Sánchez-Margalet
Sep 11, 2016·The Journal of Endocrinology·Baiba Steinbrekera, Robert Roghair
May 31, 2013·Biology of Reproduction·Antonio Pérez-PérezVíctor Sánchez-Margalet
Jan 24, 2002·Biology of Reproduction·Lorraine GamblingHarry J McArdle
Oct 20, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·R ZemetS Mazaki-Tovi
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Rekha BajoriaRatna Chatterjee
Aug 29, 2016·Hormone Molecular Biology and Clinical Investigation·Jorge R Pasqualini, Gérard S Chetrite
Jul 12, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Antonio Pérez-PérezVíctor Sánchez-Margalet
Dec 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Shali Mazaki-ToviEyal Sivan

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