Fetal liver disease may precede extrahepatic siderosis in neonatal hemochromatosis

Gastroenterology
J HoogstratenA S Knisely

Abstract

Three children of a mother with biopsy-confirmed posttransfusional hepatitis of undetermined etiology (non-A, non-B hepatitis) died in utero or in infancy. All had liver disease of intrauterine onset. The two liveborn children died of the consequences of severe hepatic insufficiency manifest at birth and met clinicopathologic criteria for neonatal hemochromatosis. Although hepatic architecture in the stillborn fetus was markedly disordered, with hepatocyte giant cell transformation, extrahepatic siderosis was not present and hepatic siderosis was minimal. These findings indicate that in some cases of neonatal hemochromatosis, extrahepatic siderosis may be caused by hepatic injury rather than primarily due to excessive transport of iron from mother to fetus and support speculation that in some instances an infective agent may be responsible.

Citations

May 1, 1991·Pediatric Pathology·K E BoveM W Tabor
Mar 1, 1995·European Journal of Pediatrics·J JääskeläinenK Heinonen
Aug 27, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·G P Jevon, J E Dimmick
Sep 24, 2005·Pediatric Transplantation·Peter F WhitingtonUdeme D Ekong
Apr 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Peter F Whitington, Padmini Malladi
Oct 31, 2013·Clinical & Developmental Immunology·Daniel S SmykDiego Vergani
Jun 24, 1999·Journal of Perinatal Medicine·E KassemD Kidron
Dec 23, 1999·The New England Journal of Medicine·N C Andrews
Oct 8, 2009·Pediatric Research·Silvana F BonillaPeter F Whitington
Apr 12, 2013·Journal of Magnetic Resonance Imaging : JMRI·Orly GoiteinEli Konen
Aug 21, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Sophie Collardeau-FrachonVincent Guigonis
Jul 1, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomoyuki TsunodaTomoo Fujisawa
Nov 1, 1990·American Journal of Medical Genetics·J DalhøjA S Knisely
Nov 10, 2001·Annual Review of Genomics and Human Genetics·N C Andrews
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter F Whitington
Mar 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Ayano InuiYutaka Kagata
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaomin PanPeter F Whitington
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fernanda RodriguesGiorgina Mieli-Vergani
Nov 1, 1992·American Journal of Medical Genetics·L FerrellS Packman
Mar 14, 2002·Critical Reviews in Clinical Laboratory Sciences·M S Tanner
Jan 3, 2021·NeoReviews·Rahul J D'MelloTinnakorn Chaiworapongsa
Nov 18, 2005·Pediatrics·Udeme D EkongPeter F Whitington

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.