PMID: 2510616Oct 1, 1989Paper

Fetal loss treatment in patients with antiphospholipid antibodies

Annals of the Rheumatic Diseases
J OrdiE Genover

Abstract

A group of seven young women with antiphospholipid antibodies, histories of recurrent fetal loss, and no live births is reported. Two patients had systemic lupus erythematosus, and the other five fulfilled criteria for the primary antiphospholipid syndrome. A false Venereal Disease Research Laboratory (VDRL) test was present in four of the patients, three had a previous episode of arterial or venous thrombosis, or both, and two had thrombocytopenia. Prednisone and acetylsalicylic acid were given, and monthly controls of lupus anticoagulant activity were carried out. The dose of acetylsalicylic acid was fixed while the dose of steroids was adjusted according to the degree of lupus anticoagulant activity. A fetal survival was obtained in 7/9 (78%) of the pregnancies. Three of the newborn infants had transitory lupus anticoagulant activity. A search for antiphospholipid antibodies should be carried out in patients with otherwise unexplained fetal losses, falsely positive VDRL tests, thrombosis, or thrombocytopenia as the treatment of such patients with prednisone and acetylsalicylic acid is highly effective.

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Citations

Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron, G Frampton
Jun 1, 1992·Journal of Reproductive Immunology·T W LydenN S Rote
Jun 9, 1998·Journal of Reproductive Immunology·D W Branch
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Feb 24, 2001·Clinical Obstetrics and Gynecology·M S Esplin
Apr 1, 1993·American Journal of Reproductive Immunology : AJRI·I KrauseY Shoenfeld
Apr 2, 1999·American Journal of Reproductive Immunology : AJRI·W H KuttehR Silver
Oct 1, 1989·Annals of the Rheumatic Diseases·M J Walport
Jul 1, 1992·American Journal of Obstetrics and Gynecology·H J OutR H Derksen
Apr 1, 1990·Baillière's Clinical Rheumatology·E N Harris
Oct 1, 1992·The American Journal of Medicine·L H SilveiraL R Espinoza
Feb 1, 1997·Rheumatic Diseases Clinics of North America·L ZiporenY Shoenfeld
Oct 6, 1998·Scandinavian Journal of Rheumatology. Supplement·E N Harris, S S Pierangeli
Oct 1, 1990·Seminars in Arthritis and Rheumatism·L R SammaritanoM D Lockshin

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