Fetal metabolic response to endogenous insulin release

American Journal of Obstetrics and Gynecology
A F PhilippsJ R Raye

Abstract

The fetal metabolic response to tolbutamide-induced insulin release was evaluated in nine chronically catheterized fetal lambs. Tolbutamide produced an elevation in fetal insulin that persisted throughout the 1-hour experimental period (peak insulin concentration achieved was 76.1 +/- 9.5 micro U/ml). Fetal hyperinsulinemia was associated with a fall by 30 minutes in both fetal arterial and umbilical venous glucose concentrations as well as an increase in the umbilical glucose venous-arterial difference. This increase was associated with an elevation of fetal glucose uptake 65.6% +/- 29.6% above control at 30 minutes after infusion. Fetal arterial oxygen content fell after tolbutamide administration and was accompanied by an increase in the umbilical venous-arterial oxygen content difference (13.0% +/- 5.0% above the basal level.) Despite the increased venous-arterial difference, however, no change in umbilical oxygen consumption was noted. Isolated endogenous fetal insulin release is thus associated with a relatively rapid increase in umbilical glucose uptake as well as concomitant fetal hypoglycemia. The etiology of the mild fetal hypoxemia produced is unclear. The alterations in fetal glucose uptake in the ovine fetus after ...Continue Reading

References

Dec 1, 1979·Pediatric Research·A F PhilippsJ R Raye
Feb 1, 1978·Pediatric Research·M A SimmonsG Meschia
Oct 1, 1970·Endocrinology·J R ColwillF C Battaglia

❮ Previous
Next ❯

Citations

Mar 1, 1989·American Journal of Obstetrics and Gynecology·B S StonestreetB T Jackson
Sep 21, 2007·American Journal of Obstetrics and Gynecology·Jeremy McCallumBryan S Richardson
Oct 19, 2000·The New England Journal of Medicine·M F Greene
Mar 15, 1993·Annals of the New York Academy of Sciences·L Jovanovic-Peterson, C M Peterson
Dec 1, 1990·Diabetes/metabolism Reviews·L AertsF A Van Assche
Oct 1, 1986·The American Journal of Physiology·C A BlochM A Sperling
Sep 9, 1985·Biochimica Et Biophysica Acta·D L Yudilevich, J H Sweiry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.