Fetal metabolic responses to hypoxia

Reproduction, Fertility, and Development
S B Hooper

Abstract

It has been known for may years that hypoxaemia in the fetus induces a number of biophysical, cardiovascular, endocrine and metabolic responses by the fetus, some of which are not sustained if the period of hypoxaemia is extended. For instance, fetal breathing and body movements and the circulating concentrations of many of the stress-related hormones return to control levels during prolonged periods of hypoxaemia. In particular, circulating fetal blood glucose concentrations gradually return to control levels, after an initial increase. The initial increase is primarily due to a catecholamine-mediated increase in glucose production from glycogen stores leading to a marked reduction in glycogen content. During prolonged periods of hypoxaemia, however, the decrease in fetal blood glucose concentrations is principally due to a decrease in the activity of the major enzymes responsible for glycogenolysis and not to a total depletion of glycogen stores. It is suggested that the decrease in enzyme activity could be due to a prostaglandin E2-mediated antagonism of catecholamine-activated glycogenolysis. In contrast, fetal blood lactate concentrations increase to a plateau after 4-5 h of hypoxaemia and remain at this elevated level for...Continue Reading

Citations

Oct 16, 2012·Seminars in Cell & Developmental Biology·Chandan K Sen, Sashwati Roy
May 31, 2011·Respiratory Physiology & Neurobiology·Henning Schneider
Jan 10, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·V G SupramaniamS L Miller
Jun 25, 1999·Metabolism: Clinical and Experimental·F SakerS C Kalhan
Apr 25, 2015·Journal of Pineal Research·Avnesh S ThakorDino A Giussani
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·D W Walker
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D A GiussaniA J Fletcher
Jun 1, 1997·Equine Veterinary Journal. Supplement·A L Fowden
Oct 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A S Thakor, D A Giussani
Mar 2, 2019·Brain Sciences·Shiraz BadurdeenGraeme Polglase
Aug 13, 1999·The American Journal of Physiology·M A BraaksmaJ G Aarnoudse

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