PMID: 2174490Jan 1, 1990Paper

Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues

Life Sciences
T A SlotkinF J Seidler

Abstract

Gestational exposure to nicotine has been shown to affect development of noradrenergic activity in both the central and peripheral nervous systems. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump implants. After birth, offspring of the nicotine-infused dams exhibited marked increases in basal adenylate cyclase activity in membranes prepared from kidney and heart, as well as supersensitivity to stimulation by either a beta-adrenergic agonist, isoproterenol, or by forskolin. The altered responses were not accompanied by up-regulation of beta-adrenergic receptors: in fact, [125I]pindolol binding was significantly decreased in the nicotine group. These results indicate that fetal nicotine exposure affects enzymes involved in membrane receptor signal transduction, leading to altered responsiveness independently of changes at the receptor level.

References

Apr 27, 1987·Life Sciences·L C MurrinN J Haley
Jan 1, 1986·Biology of the Neonate·H A NasratF A Mahmood
Apr 7, 1972·Nature·P F Isaac, M J Rand

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Citations

Mar 1, 1993·Neurotoxicology and Teratology·E A ZahalkaT A Slotkin
Dec 18, 2001·Brain Research. Developmental Brain Research·T A SlotkinJ Yanai
Feb 24, 2000·International Journal of Immunopharmacology·P V BastaH A Navarro
Nov 5, 2003·Environmental Health Perspectives·Justin E AldridgeTheodore A Slotkin
May 7, 1999·Environmental Health Perspectives·T A Slotkin
Jan 1, 1996·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·T A SlotkinF J Seidler
Sep 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Theodore A SlotkinFrederic J Seidler
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D A Dempsey, N L Benowitz
Jul 10, 2002·Annals of the New York Academy of Sciences·Joseph YanaiTheodore A Slotkin
Nov 1, 1993·The International Journal of the Addictions·M Behnke, F D Eyler

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