PMID: 6991163Jan 1, 1980Paper

Fetal origin of amniotic fluid insulin in the human mother

Clinical Endocrinology
A V GrecoG Ghirlanda

Abstract

To investigate the origin of insulin in amniotic fluid amniocenteses were carried out in pregnancies with live, dead and anencephalic fetuses. Amniotic fluid insulin of pregnant women bearing live fetuses was 9.0 +/- 2.1 microU/ml; in six women with dead foetuses amniotic fluid insulin was not detected. A significant positive correlation was observed between gestational age and the amniotic fluid concentration of insulin. In the amniotic fluid of the four women bearing anencephalic fetuses, the amount of hormone was within normal limits (10.0 +/- 1.4 microU/ml). Intravenous glucose administration (0.33 g/kg body weight) to the mother doses not influence levels of insulin in amniotic fluid, but brought about changes in amniotic fluid glucose concentration. These findings support the conclusion that human amniotic fluid insulin is of fetal rather than maternal origin.

References

Mar 1, 1972·The Journal of Endocrinology·R D MilnerA J Barson
May 29, 1970·Science· Espinosa de los MonterosJ Steinke
Jan 1, 1969·Biologia Neonatorum. Neo-natal Studies·F A Van AsscheM De Gasparo
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Sep 10, 1970·The New England Journal of Medicine·S S ObenshainR Schwartz
Sep 1, 1957·American Journal of Obstetrics and Gynecology·J DAVIES, P E LACY
Jan 1, 1960·The Journal of Clinical Investigation·N FREINKEL, C J GOODNER
Jan 1, 1962·The Journal of Clinical Investigation·M G BUSEJ BUSE

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Citations

Jan 16, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Roland Gregor SteinUrsula Zollner
Jul 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·M LeggeD R Aickin
Sep 3, 2011·Archives of Sexual Behavior·Carol C WeisfeldJiliang Shen
Sep 1, 1985·Journal of Clinical Ultrasound : JCU·P JouppilaP Kirkinen

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